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The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.
Diaz-Gonzalez R, Kuhlmann FM, Galan-Rodriguez C, Madeira da Silva L, Saldivia M, Karver CE, Rodriguez A, Beverley SM, Navarro M, Pollastri MP. Diaz-Gonzalez R, et al. Among authors: karver ce. PLoS Negl Trop Dis. 2011 Aug;5(8):e1297. doi: 10.1371/journal.pntd.0001297. Epub 2011 Aug 23. PLoS Negl Trop Dis. 2011. PMID: 21886855 Free PMC article.
Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases.
Kent CR, Bryja M, Gustafson HA, Kawarski MY, Lenti G, Pierce EN, Knopp RC, Ceja V, Pati B, Walters DE, Karver CE. Kent CR, et al. Among authors: karver ce. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5476-5480. doi: 10.1016/j.bmcl.2016.10.025. Epub 2016 Oct 12. Bioorg Med Chem Lett. 2016. PMID: 27777011
pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays.
Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. Stanford SM, et al. Among authors: karver ce. Methods. 2014 Jan 15;65(2):165-74. doi: 10.1016/j.ymeth.2013.07.022. Epub 2013 Jul 22. Methods. 2014. PMID: 23886911 Free PMC article. Review.