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The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.
Diaz-Gonzalez R, Kuhlmann FM, Galan-Rodriguez C, Madeira da Silva L, Saldivia M, Karver CE, Rodriguez A, Beverley SM, Navarro M, Pollastri MP. Diaz-Gonzalez R, et al. Among authors: navarro m. PLoS Negl Trop Dis. 2011 Aug;5(8):e1297. doi: 10.1371/journal.pntd.0001297. Epub 2011 Aug 23. PLoS Negl Trop Dis. 2011. PMID: 21886855 Free PMC article.
Diamine and aminoalcohol derivatives active against Trypanosoma brucei.
Olmo ED, Diaz-González R, Escarcena R, Carvalho L, Bustos LA, Navarro M, Feliciano AS. Olmo ED, et al. Among authors: navarro m. Bioorg Med Chem Lett. 2012 Jan 1;22(1):440-3. doi: 10.1016/j.bmcl.2011.10.108. Epub 2011 Nov 6. Bioorg Med Chem Lett. 2012. PMID: 22119463
Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness.
Seixas JD, Luengo-Arratta SA, Diaz R, Saldivia M, Rojas-Barros DI, Manzano P, Gonzalez S, Berlanga M, Smith TK, Navarro M, Pollastri MP. Seixas JD, et al. Among authors: navarro m. J Med Chem. 2014 Jun 12;57(11):4834-48. doi: 10.1021/jm500361r. Epub 2014 May 21. J Med Chem. 2014. PMID: 24805946 Free PMC article.
Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.
Diaz R, Luengo-Arratta SA, Seixas JD, Amata E, Devine W, Cordon-Obras C, Rojas-Barros DI, Jimenez E, Ortega F, Crouch S, Colmenarejo G, Fiandor JM, Martin JJ, Berlanga M, Gonzalez S, Manzano P, Navarro M, Pollastri MP. Diaz R, et al. Among authors: navarro m. PLoS Negl Trop Dis. 2014 Oct 23;8(10):e3253. doi: 10.1371/journal.pntd.0003253. eCollection 2014 Oct. PLoS Negl Trop Dis. 2014. PMID: 25340575 Free PMC article.
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
Peña I, Pilar Manzano M, Cantizani J, Kessler A, Alonso-Padilla J, Bardera AI, Alvarez E, Colmenarejo G, Cotillo I, Roquero I, de Dios-Anton F, Barroso V, Rodriguez A, Gray DW, Navarro M, Kumar V, Sherstnev A, Drewry DH, Brown JR, Fiandor JM, Julio Martin J. Peña I, et al. Among authors: navarro m. Sci Rep. 2015 Mar 5;5:8771. doi: 10.1038/srep08771. Sci Rep. 2015. PMID: 25740547 Free PMC article.
Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?
Amata E, Xi H, Colmenarejo G, Gonzalez-Diaz R, Cordon-Obras C, Berlanga M, Manzano P, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Navarro M, Pollastri MP. Amata E, et al. Among authors: navarro m. ACS Infect Dis. 2016 Mar 11;2(3):180-186. doi: 10.1021/acsinfecdis.5b00136. Epub 2016 Jan 17. ACS Infect Dis. 2016. PMID: 26998514 Free PMC article.
2,680 results