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Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
Bousejra-El Garah F, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL, Park BK, Chadwick J, Ward SA, O'Neill PM. Bousejra-El Garah F, et al. Among authors: chadwick j. J Med Chem. 2011 Oct 13;54(19):6443-55. doi: 10.1021/jm200768h. Epub 2011 Sep 19. J Med Chem. 2011. PMID: 21888440
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. Gibbons P, et al. Among authors: chadwick j. J Med Chem. 2010 Nov 25;53(22):8202-6. doi: 10.1021/jm1009567. Epub 2010 Oct 27. J Med Chem. 2010. PMID: 20979352
Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.
Sharma R, Lawrenson AS, Fisher NE, Warman AJ, Shone AE, Hill A, Mbekeani A, Pidathala C, Amewu RK, Leung S, Gibbons P, Hong DW, Stocks P, Nixon GL, Chadwick J, Shearer J, Gowers I, Cronk D, Parel SP, O'Neill PM, Ward SA, Biagini GA, Berry NG. Sharma R, et al. Among authors: chadwick j. J Med Chem. 2012 Apr 12;55(7):3144-54. doi: 10.1021/jm3001482. Epub 2012 Mar 22. J Med Chem. 2012. PMID: 22380711 Free PMC article.
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
O'Neill PM, Amewu RK, Nixon GL, Bousejra ElGarah F, Mungthin M, Chadwick J, Shone AE, Vivas L, Lander H, Barton V, Muangnoicharoen S, Bray PG, Davies J, Park BK, Wittlin S, Brun R, Preschel M, Zhang K, Ward SA. O'Neill PM, et al. Among authors: chadwick j. Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5693-7. doi: 10.1002/anie.201001026. Angew Chem Int Ed Engl. 2010. PMID: 20629058 No abstract available.
260 results