Horuk R - Search Results

1

Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3.

Nedjai B, Li H, Stroke IL, Wise EL, Webb ML, Merritt JR, Henderson I, Klon AE, Cole AG, Horuk R, Vaidehi N, Pease JE. Nedjai B, et al. Among authors: horuk r. Br J Pharmacol. 2012 Jun;166(3):912-23. doi: 10.1111/j.1476-5381.2011.01660.x. Br J Pharmacol. 2012. PMID: 21895630 Free PMC article.

2

Small molecule antagonists of chemokine receptors--is promiscuity a virtue?

Pease JE, Horuk R. Pease JE, et al. Among authors: horuk r. Curr Top Med Chem. 2010;10(13):1351-8. doi: 10.2174/156802610791561228. Curr Top Med Chem. 2010. PMID: 20536423 Review.

3

CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779.

Nedjai B, Viney JM, Li H, Hull C, Anderson CA, Horie T, Horuk R, Vaidehi N, Pease JE. Nedjai B, et al. Among authors: horuk r. Br J Pharmacol. 2015 Apr;172(7):1822-33. doi: 10.1111/bph.13027. Epub 2015 Feb 10. Br J Pharmacol. 2015. PMID: 25425280 Free PMC article.

4

Chemokine receptor antagonists: Part 1.

Pease JE, Horuk R. Pease JE, et al. Among authors: horuk r. Expert Opin Ther Pat. 2009 Jan;19(1):39-58. doi: 10.1517/13543770802641346. Expert Opin Ther Pat. 2009. PMID: 19441897 Review.

5

Chemokine receptor antagonists: part 2.

Pease JE, Horuk R. Pease JE, et al. Among authors: horuk r. Expert Opin Ther Pat. 2009 Feb;19(2):199-221. doi: 10.1517/13543770802641353. Expert Opin Ther Pat. 2009. PMID: 19441918 Review.

6

Modeling small molecule-compound binding to G-protein-coupled receptors.

Vaidehi N, Pease JE, Horuk R. Vaidehi N, et al. Among authors: horuk r. Methods Enzymol. 2009;460:263-88. doi: 10.1016/S0076-6879(09)05213-6. Methods Enzymol. 2009. PMID: 19446730

7

Chemokine receptor antagonists.

Pease J, Horuk R. Pease J, et al. Among authors: horuk r. J Med Chem. 2012 Nov 26;55(22):9363-92. doi: 10.1021/jm300682j. Epub 2012 Sep 24. J Med Chem. 2012. PMID: 22931505 No abstract available.

8

Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4.

Pease JE, Horuk R. Pease JE, et al. Among authors: horuk r. Expert Opin Drug Discov. 2014 May;9(5):467-83. doi: 10.1517/17460441.2014.897324. Epub 2014 Mar 18. Expert Opin Drug Discov. 2014. PMID: 24641500 Review.

9

CCR1 antagonists in clinical development.

Pease JE, Horuk R. Pease JE, et al. Among authors: horuk r. Expert Opin Investig Drugs. 2005 Jul;14(7):785-96. doi: 10.1517/13543784.14.7.785. Expert Opin Investig Drugs. 2005. PMID: 16022568 Review.

10

Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.

Hall SE, Mao A, Nicolaidou V, Finelli M, Wise EL, Nedjai B, Kanjanapangka J, Harirchian P, Chen D, Selchau V, Ribeiro S, Schyler S, Pease JE, Horuk R, Vaidehi N. Hall SE, et al. Among authors: horuk r. Mol Pharmacol. 2009 Jun;75(6):1325-36. doi: 10.1124/mol.108.053470. Epub 2009 Mar 18. Mol Pharmacol. 2009. PMID: 19297521

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