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Page 1
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. Tammela T, et al. Among authors: zarkada g. Nat Cell Biol. 2011 Sep 11;13(10):1202-13. doi: 10.1038/ncb2331. Nat Cell Biol. 2011. PMID: 21909098 Free PMC article.
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Tammela T, et al. Among authors: zarkada g. Nature. 2008 Jul 31;454(7204):656-60. doi: 10.1038/nature07083. Epub 2008 Jun 25. Nature. 2008. PMID: 18594512
Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.
Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K. Holopainen T, et al. Among authors: zarkada g. J Natl Cancer Inst. 2012 Mar 21;104(6):461-75. doi: 10.1093/jnci/djs009. Epub 2012 Feb 17. J Natl Cancer Inst. 2012. PMID: 22343031 Free PMC article.
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.
D'Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Eklund L, Sormunen R, Elamaa H, Brekken RA, Adams RH, Koh GY, Saharinen P, Alitalo K. D'Amico G, et al. Among authors: zarkada g. J Clin Invest. 2014 Feb;124(2):824-34. doi: 10.1172/JCI68897. Epub 2014 Jan 16. J Clin Invest. 2014. PMID: 24430181 Free PMC article.
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K. Aspelund A, et al. Among authors: zarkada g. J Clin Invest. 2014 Sep;124(9):3975-86. doi: 10.1172/JCI75395. Epub 2014 Jul 25. J Clin Invest. 2014. PMID: 25061878 Free PMC article.
VEGFR3 does not sustain retinal angiogenesis without VEGFR2.
Zarkada G, Heinolainen K, Makinen T, Kubota Y, Alitalo K. Zarkada G, et al. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):761-6. doi: 10.1073/pnas.1423278112. Epub 2015 Jan 5. Proc Natl Acad Sci U S A. 2015. PMID: 25561555 Free PMC article.
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