Doyle PS - Search Results

1

The Trypanosoma cruzi protease cruzain mediates immune evasion.

Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. Doyle PS, et al. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. PLoS Pathog. 2011. PMID: 21909255 Free PMC article.

2

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

3

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

4

A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.

Doyle PS, Zhou YM, Engel JC, McKerrow JH. Doyle PS, et al. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9. doi: 10.1128/AAC.00436-07. Epub 2007 Aug 13. Antimicrob Agents Chemother. 2007. PMID: 17698625 Free PMC article.

5

Identification of a new class of nonpeptidic inhibitors of cruzain.

Brak K, Doyle PS, McKerrow JH, Ellman JA. Brak K, et al. Among authors: doyle ps. J Am Chem Soc. 2008 May 21;130(20):6404-10. doi: 10.1021/ja710254m. Epub 2008 Apr 25. J Am Chem Soc. 2008. PMID: 18435536 Free PMC article.

6

Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.

Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Brak K, et al. Among authors: doyle ps. J Med Chem. 2010 Feb 25;53(4):1763-73. doi: 10.1021/jm901633v. J Med Chem. 2010. PMID: 20088534 Free PMC article.

7

Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.

Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. Engel JC, et al. Among authors: doyle ps. Antimicrob Agents Chemother. 2010 Aug;54(8):3326-34. doi: 10.1128/AAC.01777-09. Epub 2010 Jun 14. Antimicrob Agents Chemother. 2010. PMID: 20547819 Free PMC article.

8

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. Chen YT, et al. Among authors: doyle ps. PLoS Negl Trop Dis. 2010 Sep 14;4(9):e825. doi: 10.1371/journal.pntd.0000825. PLoS Negl Trop Dis. 2010. PMID: 20856868 Free PMC article.

9

Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.

Engel JC, Doyle PS, Palmer J, Hsieh I, Bainton DF, McKerrow JH. Engel JC, et al. Among authors: doyle ps. J Cell Sci. 1998 Mar;111 ( Pt 5):597-606. doi: 10.1242/jcs.111.5.597. J Cell Sci. 1998. PMID: 9454733

10

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection.

Engel JC, Doyle PS, Hsieh I, McKerrow JH. Engel JC, et al. Among authors: doyle ps. J Exp Med. 1998 Aug 17;188(4):725-34. doi: 10.1084/jem.188.4.725. J Exp Med. 1998. PMID: 9705954 Free PMC article.

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