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Page 1
Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.
Kumadaki S, Karasawa T, Matsuzaka T, Ema M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, Shimano H. Kumadaki S, et al. Among authors: karasawa t. J Biol Chem. 2011 Nov 25;286(47):40835-46. doi: 10.1074/jbc.M111.235283. Epub 2011 Sep 12. J Biol Chem. 2011. PMID: 21911492 Free PMC article.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N. Matsuzaka T, et al. Among authors: karasawa t. Nat Med. 2007 Oct;13(10):1193-202. doi: 10.1038/nm1662. Epub 2007 Sep 30. Nat Med. 2007. PMID: 17906635
Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.
Karasawa T, Takahashi A, Saito R, Sekiya M, Igarashi M, Iwasaki H, Miyahara S, Koyasu S, Nakagawa Y, Ishii K, Matsuzaka T, Kobayashi K, Yahagi N, Takekoshi K, Sone H, Yatoh S, Suzuki H, Yamada N, Shimano H. Karasawa T, et al. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1788-95. doi: 10.1161/ATVBAHA.110.219659. Epub 2011 May 5. Arterioscler Thromb Vasc Biol. 2011. PMID: 21546605
Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H. Saito R, et al. Among authors: karasawa t. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1973-9. doi: 10.1161/ATVBAHA.110.221663. Epub 2011 Aug 4. Arterioscler Thromb Vasc Biol. 2011. PMID: 21817094
Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: karasawa t. Endocrinology. 2014 Dec;155(12):4706-19. doi: 10.1210/en.2014-1113. Epub 2014 Sep 18. Endocrinology. 2014. PMID: 25233440
Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M. Karasawa T, et al. Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):744-756. doi: 10.1161/ATVBAHA.117.310581. Epub 2018 Feb 8. Arterioscler Thromb Vasc Biol. 2018. PMID: 29437575
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis.
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M. Yamada N, et al. Among authors: karasawa t. Nat Commun. 2024 Mar 12;15(1):2195. doi: 10.1038/s41467-024-46386-6. Nat Commun. 2024. PMID: 38472233 Free PMC article.
NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M. Mizushina Y, et al. Among authors: karasawa t. J Biol Chem. 2015 Feb 20;290(8):5065-5077. doi: 10.1074/jbc.M114.603217. Epub 2014 Dec 29. J Biol Chem. 2015. PMID: 25548278 Free PMC article.
Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow.
Wakabayashi T, Takahashi M, Yamamuro D, Karasawa T, Takei A, Takei S, Yamazaki H, Nagashima S, Ebihara K, Takahashi M, Ishibashi S. Wakabayashi T, et al. Among authors: karasawa t. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2576-2589. doi: 10.1161/ATVBAHA.118.311648. Arterioscler Thromb Vasc Biol. 2018. PMID: 30354239 Free article.
ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.
Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M. Komada T, et al. Among authors: karasawa t. Am J Pathol. 2014 May;184(5):1287-98. doi: 10.1016/j.ajpath.2014.01.014. Epub 2014 Mar 5. Am J Pathol. 2014. PMID: 24606883 Free article.
321 results