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Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.
Philips GM, Chan IS, Swiderska M, Schroder VT, Guy C, Karaca GF, Moylan C, Venkatraman T, Feuerlein S, Syn WK, Jung Y, Witek RP, Choi S, Michelotti GA, Rangwala F, Merkle E, Lascola C, Diehl AM. Philips GM, et al. Among authors: chan is. PLoS One. 2011;6(9):e23943. doi: 10.1371/journal.pone.0023943. Epub 2011 Sep 2. PLoS One. 2011. PMID: 21912653 Free PMC article.
Hedgehog controls hepatic stellate cell fate by regulating metabolism.
Chen Y, Choi SS, Michelotti GA, Chan IS, Swiderska-Syn M, Karaca GF, Xie G, Moylan CA, Garibaldi F, Premont R, Suliman HB, Piantadosi CA, Diehl AM. Chen Y, et al. Among authors: chan is. Gastroenterology. 2012 Nov;143(5):1319-1329.e11. doi: 10.1053/j.gastro.2012.07.115. Epub 2012 Aug 8. Gastroenterology. 2012. PMID: 22885334 Free PMC article.
Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.
Chan IS, Guy CD, Chen Y, Lu J, Swiderska-Syn M, Michelotti GA, Karaca G, Xie G, Krüger L, Syn WK, Anderson BR, Pereira TA, Choi SS, Baldwin AS, Diehl AM. Chan IS, et al. Cancer Res. 2012 Dec 15;72(24):6344-50. doi: 10.1158/0008-5472.CAN-12-1068. Epub 2012 Oct 12. Cancer Res. 2012. PMID: 23066040 Free PMC article.
Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.
Chan IS, Guy CD, Machado MV, Wank A, Kadiyala V, Michelotti G, Choi S, Swiderska-Syn M, Karaca G, Pereira TA, Yip-Schneider MT, Max Schmidt C, Diehl AM. Chan IS, et al. Alcohol Clin Exp Res. 2014 Mar;38(3):787-800. doi: 10.1111/acer.12279. Epub 2013 Oct 24. Alcohol Clin Exp Res. 2014. PMID: 24164383 Free PMC article.
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
Pereira TA, Syn WK, Machado MV, Vidigal PV, Resende V, Voieta I, Xie G, Otoni A, Souza MM, Santos ET, Chan IS, Trindade GV, Choi SS, Witek RP, Pereira FE, Secor WE, Andrade ZA, Lambertucci JR, Diehl AM. Pereira TA, et al. Among authors: chan is. Clin Sci (Lond). 2015 Nov;129(10):875-83. doi: 10.1042/CS20150117. Epub 2015 Jul 21. Clin Sci (Lond). 2015. PMID: 26201095 Free PMC article.
Personalized medicine: progress and promise.
Chan IS, Ginsburg GS. Chan IS, et al. Annu Rev Genomics Hum Genet. 2011;12:217-44. doi: 10.1146/annurev-genom-082410-101446. Annu Rev Genomics Hum Genet. 2011. PMID: 21721939 Review.
128 results