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F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103.
Etiévant C, Kruczynski A, Barret JM, Perrin D, van Hille B, Guminski Y, Hill BT. Etiévant C, et al. Among authors: kruczynski a. Cancer Chemother Pharmacol. 2000;46(2):101-13. doi: 10.1007/s002800000133. Cancer Chemother Pharmacol. 2000. PMID: 10972479
Antitumor pharmacology -- quo vadis?
Bailly C, Barret JM, Kruczynski A. Bailly C, et al. Among authors: kruczynski a. Curr Med Chem Anticancer Agents. 2004 Sep;4(5):389-91. doi: 10.2174/1568011043352849. Curr Med Chem Anticancer Agents. 2004. PMID: 15379689 Review.
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