Le Floch R - Search Results

1

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.

Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J. Le Floch R, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16663-8. doi: 10.1073/pnas.1106123108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930917 Free PMC article.

2

Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.

Marchiq I, Le Floch R, Roux D, Simon MP, Pouyssegur J. Marchiq I, et al. Among authors: le floch r. Cancer Res. 2015 Jan 1;75(1):171-80. doi: 10.1158/0008-5472.CAN-14-2260. Epub 2014 Nov 17. Cancer Res. 2015. PMID: 25403912

3

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.

Granja S, Marchiq I, Le Floch R, Moura CS, Baltazar F, Pouysségur J. Granja S, et al. Among authors: le floch r. Oncotarget. 2015 Mar 30;6(9):6708-21. doi: 10.18632/oncotarget.2862. Oncotarget. 2015. PMID: 25894929 Free PMC article.

4

Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels.

Lefloch R, Pouysségur J, Lenormand P. Lefloch R, et al. Mol Cell Biol. 2008 Jan;28(1):511-27. doi: 10.1128/MCB.00800-07. Epub 2007 Oct 29. Mol Cell Biol. 2008. PMID: 17967895 Free PMC article.

5

Total ERK1/2 activity regulates cell proliferation.

Lefloch R, Pouysségur J, Lenormand P. Lefloch R, et al. Cell Cycle. 2009 Mar 1;8(5):705-11. doi: 10.4161/cc.8.5.7734. Epub 2009 Mar 29. Cell Cycle. 2009. PMID: 19242111

6

ERK implication in cell cycle regulation.

Chambard JC, Lefloch R, Pouysségur J, Lenormand P. Chambard JC, et al. Biochim Biophys Acta. 2007 Aug;1773(8):1299-310. doi: 10.1016/j.bbamcr.2006.11.010. Epub 2006 Nov 17. Biochim Biophys Acta. 2007. PMID: 17188374 Free article. Review.

7

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.

Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutté E, Massard PA, de la Ballina LR, Endou H, Wempe MF, Palacin M, Parks SK, Pouyssegur J. Cormerais Y, et al. Cancer Res. 2016 Aug 1;76(15):4481-92. doi: 10.1158/0008-5472.CAN-15-3376. Epub 2016 Jun 14. Cancer Res. 2016. PMID: 27302165

8

Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.

Sutton KM, Hayat S, Chau NM, Cook S, Pouyssegur J, Ahmed A, Perusinghe N, Le Floch R, Yang J, Ashcroft M. Sutton KM, et al. Among authors: le floch r. Oncogene. 2007 Jun 7;26(27):3920-9. doi: 10.1038/sj.onc.1210168. Epub 2007 Jan 8. Oncogene. 2007. PMID: 17213817

9

TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.

Jousse C, Deval C, Maurin AC, Parry L, Chérasse Y, Chaveroux C, Lefloch R, Lenormand P, Bruhat A, Fafournoux P. Jousse C, et al. J Biol Chem. 2007 May 25;282(21):15851-61. doi: 10.1074/jbc.M611723200. Epub 2007 Mar 16. J Biol Chem. 2007. PMID: 17369260 Free article.

10

Nm23-M2/NDP kinase B induces endogenous c-myc and nm23-M1/NDP kinase A overexpression in BAF3 cells. Both NDP kinases protect the cells from oxidative stress-induced death.

Arnaud-Dabernat S, Masse K, Smani M, Peuchant E, Landry M, Bourbon PM, Le Floch R, Daniel JY, Larou M. Arnaud-Dabernat S, et al. Among authors: le floch r. Exp Cell Res. 2004 Dec 10;301(2):293-304. doi: 10.1016/j.yexcr.2004.07.026. Exp Cell Res. 2004. PMID: 15530864

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