Wetzel M - Search Results

1

Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis.

Wetzel M, Gargano EM, Hinsberger S, Marchais-Oberwinkler S, Hartmann RW. Wetzel M, et al. Eur J Med Chem. 2012 Jan;47(1):1-17. doi: 10.1016/j.ejmech.2011.09.004. Epub 2011 Sep 8. Eur J Med Chem. 2012. PMID: 21945251

2

New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.

Marchais-Oberwinkler S, Wetzel M, Ziegler E, Kruchten P, Werth R, Henn C, Hartmann RW, Frotscher M. Marchais-Oberwinkler S, et al. Among authors: wetzel m. J Med Chem. 2011 Jan 27;54(2):534-47. doi: 10.1021/jm1009082. Epub 2010 Dec 28. J Med Chem. 2011. PMID: 21189020

3

17β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffold.

Wetzel M, Marchais-Oberwinkler S, Hartmann RW. Wetzel M, et al. Bioorg Med Chem. 2011 Jan 15;19(2):807-15. doi: 10.1016/j.bmc.2010.12.013. Epub 2010 Dec 9. Bioorg Med Chem. 2011. PMID: 21211981

4

Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors.

Wetzel M, Marchais-Oberwinkler S, Perspicace E, Möller G, Adamski J, Hartmann RW. Wetzel M, et al. J Med Chem. 2011 Nov 10;54(21):7547-57. doi: 10.1021/jm2008453. Epub 2011 Oct 19. J Med Chem. 2011. PMID: 21972996

5

Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitors.

Xu K, Al-Soud YA, Wetzel M, Hartmann RW, Marchais-Oberwinkler S. Xu K, et al. Among authors: wetzel m. Eur J Med Chem. 2011 Dec;46(12):5978-90. doi: 10.1016/j.ejmech.2011.10.010. Epub 2011 Oct 10. Eur J Med Chem. 2011. PMID: 22037253

6

Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.

Marchais-Oberwinkler S, Xu K, Wetzel M, Perspicace E, Negri M, Meyer A, Odermatt A, Möller G, Adamski J, Hartmann RW. Marchais-Oberwinkler S, et al. Among authors: wetzel m. J Med Chem. 2013 Jan 10;56(1):167-81. doi: 10.1021/jm3014053. Epub 2012 Dec 19. J Med Chem. 2013. PMID: 23145773

7

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J. Marchais-Oberwinkler S, et al. Among authors: wetzel m. J Steroid Biochem Mol Biol. 2011 May;125(1-2):66-82. doi: 10.1016/j.jsbmb.2010.12.013. Epub 2010 Dec 28. J Steroid Biochem Mol Biol. 2011. PMID: 21193039 Review.

8

Multimodal treatment of glioblastoma with multiple lesions - a multi-center retrospective analysis.

Krenzlin H, Jankovic D, Dauth A, Lange F, Wetzel M, Schmidt L, Janssen I, Richter C, Stockinger M, Schmidberger H, Brockmann MA, Sommer C, Meyer B, Keric N, Ringel F. Krenzlin H, et al. Among authors: wetzel m. J Neurooncol. 2024 Dec;170(3):555-566. doi: 10.1007/s11060-024-04810-3. Epub 2024 Nov 19. J Neurooncol. 2024. PMID: 39560695 Free PMC article.

9

Oral and gut microbiome profiles in people with early idiopathic Parkinson's disease.

Stagaman K, Kmiecik MJ, Wetzel M, Aslibekyan S, Sonmez TF, Fontanillas P; 23andMe Research Team; Tung J, Holmes MV, Walk ST, Houser MC, Norcliffe-Kaufmann L. Stagaman K, et al. Among authors: wetzel m. Commun Med (Lond). 2024 Oct 23;4(1):209. doi: 10.1038/s43856-024-00630-8. Commun Med (Lond). 2024. PMID: 39443634 Free PMC article.

10

Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders.

Sidiropoulos DN, Shin SM, Wetzel M, Girgis AA, Bergman D, Danilova L, Perikala S, Shu DH, Montagne JM, Deshpande A, Leatherman J, Dequiedt L, Jacobs V, Ogurtsova A, Mo G, Yuan X, Lvovs D, Stein-O'Brien G, Yarchoan M, Zhu Q, Harper EI, Weeraratna AT, Kiemen AL, Jaffee EM, Zheng L, Ho WJ, Anders RA, Fertig EJ, Kagohara LT. Sidiropoulos DN, et al. Among authors: wetzel m. bioRxiv [Preprint]. 2024 Sep 23:2024.09.22.613714. doi: 10.1101/2024.09.22.613714. bioRxiv. 2024. PMID: 39386736 Free PMC article. Preprint.

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