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Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.
Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P. Mittal Y, et al. Among authors: pavlova y. J Biol Chem. 2011 Sep 16;286(37):32404-15. doi: 10.1074/jbc.M111.275685. Epub 2011 Jul 28. J Biol Chem. 2011. PMID: 21799016 Free PMC article.
A precision engineered interleukin-2 (IL-2) for bolstering CD8+ T- and NK-cell activity without eosinophilia and vascular leak syndrome in non-human primates.
Ma L, Acuff NV, Joseph IB, Ptacin JL, Caffaro CE, San Jose KM, Aerni HR, Carrio R, Byers AM, Herman RW, Pavlova Y, Pena MJ, Chen DB, Buetz C, Ismaili TK, Pham HV, Cucchetti M, Sassoon I, Koriazova LK, Leveque JA, Shawver LK, Mooney JM, Milla ME. Ma L, et al. Among authors: pavlova y. Cancer Res Commun. 2024 Sep 25. doi: 10.1158/2767-9764.CRC-24-0278. Online ahead of print. Cancer Res Commun. 2024. PMID: 39320047 Free article.
A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism.
Ptacin JL, Ma L, Caffaro CE, Acuff NV, Germar K, Severy P, Qu Y, Vela JL, Cai X, San Jose KM, Aerni HR, Chen DB, Esche E, Ismaili TK, Herman R, Pavlova Y, Pena MJ, Nguyen J, Koriazova LK, Shawver LK, Joseph IB, Mooney J, Peakman M, Milla ME. Ptacin JL, et al. Among authors: pavlova y. Commun Med (Lond). 2024 Mar 26;4(1):58. doi: 10.1038/s43856-024-00485-z. Commun Med (Lond). 2024. PMID: 38532017 Free PMC article.
An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Ptacin JL, Caffaro CE, Ma L, San Jose Gall KM, Aerni HR, Acuff NV, Herman RW, Pavlova Y, Pena MJ, Chen DB, Koriazova LK, Shawver LK, Joseph IB, Milla ME. Ptacin JL, et al. Among authors: pavlova y. Nat Commun. 2021 Aug 9;12(1):4785. doi: 10.1038/s41467-021-24987-9. Nat Commun. 2021. PMID: 34373459 Free PMC article.
38 results