Reddy JA - Search Results

1

Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs.

Vlahov IR, Wang Y, Vetzel M, Hahn S, Kleindl PJ, Reddy JA, Leamon CP. Vlahov IR, et al. Among authors: reddy ja. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. doi: 10.1016/j.bmcl.2011.09.041. Epub 2011 Sep 17. Bioorg Med Chem Lett. 2011. PMID: 21974954

2

Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate.

Vlahov IR, Qi L, Santhapuram HKR, Felten A, Parham GL, Zou N, Wang K, You F, Vaughn JF, Hahn SJ, Klein HF, Kleindl PJ, Reddy J, Reno D, Nicoson J, Leamon CP. Vlahov IR, et al. Bioorg Med Chem Lett. 2020 Apr 1;30(7):126987. doi: 10.1016/j.bmcl.2020.126987. Epub 2020 Jan 27. Bioorg Med Chem Lett. 2020. PMID: 32029324

3

Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic.

Leamon CP, Reddy JA, Vlahov IR, Vetzel M, Parker N, Nicoson JS, Xu LC, Westrick E. Leamon CP, et al. Among authors: reddy ja. Bioconjug Chem. 2005 Jul-Aug;16(4):803-11. doi: 10.1021/bc049709b. Bioconjug Chem. 2005. PMID: 16029021

4

Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate.

Leamon CP, Reddy JA, Vlahov IR, Kleindl PJ, Vetzel M, Westrick E. Leamon CP, et al. Among authors: reddy ja. Bioconjug Chem. 2006 Sep-Oct;17(5):1226-32. doi: 10.1021/bc060145g. Bioconjug Chem. 2006. PMID: 16984132

5

An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid.

Vlahov IR, Santhapuram HK, Wang Y, Kleindl PJ, You F, Howard SJ, Westrick E, Reddy JA, Leamon CP. Vlahov IR, et al. Among authors: reddy ja. J Org Chem. 2007 Aug 3;72(16):5968-72. doi: 10.1021/jo070411z. Epub 2007 Jun 29. J Org Chem. 2007. PMID: 17602528

6

In vivo structural activity and optimization studies of folate-tubulysin conjugates.

Reddy JA, Dorton R, Dawson A, Vetzel M, Parker N, Nicoson JS, Westrick E, Klein PJ, Wang Y, Vlahov IR, Leamon CP. Reddy JA, et al. Mol Pharm. 2009 Sep-Oct;6(5):1518-25. doi: 10.1021/mp900086w. Mol Pharm. 2009. PMID: 19630399

7

Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.

Leamon CP, Vlahov IR, Reddy JA, Vetzel M, Santhapuram HK, You F, Bloomfield A, Dorton R, Nelson M, Kleindl P, Vaughn JF, Westrick E. Leamon CP, et al. Among authors: reddy ja. Bioconjug Chem. 2014 Mar 19;25(3):560-8. doi: 10.1021/bc400441s. Epub 2014 Mar 11. Bioconjug Chem. 2014. PMID: 24564229

8

Development and validation of a UPLC-MS/MS method for the novel folate-targeted small molecule drug conjugate EC1456 and its metabolites in tumor homogenates from mice.

Rao SI, Pugh M, Nelson M, Reddy JA, Klein PJ, Leamon CP. Rao SI, et al. Among authors: reddy ja. J Pharm Biomed Anal. 2016 Apr 15;122:148-56. doi: 10.1016/j.jpba.2016.01.049. Epub 2016 Jan 25. J Pharm Biomed Anal. 2016. PMID: 26855286

9

Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy.

Leamon CP, Reddy JA, Vlahov IR, Dorton R, Bloomfield A, Vetzel M, Klein PJ, Westrick E, Xu LC, Wang Y. Leamon CP, et al. Among authors: reddy ja. Cancer Chemother Pharmacol. 2017 Jun;79(6):1151-1160. doi: 10.1007/s00280-017-3311-z. Epub 2017 Apr 27. Cancer Chemother Pharmacol. 2017. PMID: 28451831

10

Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates.

Vlahov IR, Qi L, Kleindl PJ, Santhapuram HK, Felten A, Parham GL, Wang K, You F, Vaughn JF, Hahn SJ, Klein HF, Vetzel M, Reddy JA, Nelson M, Nicoson J, Leamon CP. Vlahov IR, et al. Among authors: reddy ja. Bioconjug Chem. 2017 Dec 20;28(12):2921-2931. doi: 10.1021/acs.bioconjchem.7b00476. Epub 2017 Dec 6. Bioconjug Chem. 2017. PMID: 29211454

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