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Page 1
Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1.
Tardif KD, Rogers A, Cassiano J, Roth BL, Cimbora DM, McKinnon R, Peterson A, Douce TB, Robinson R, Dorweiler I, Davis T, Hess MA, Ostanin K, Papac DI, Baichwal V, McAlexander I, Willardsen JA, Saunders M, Christophe H, Kumar DV, Wettstein DA, Carlson RO, Williams BL. Tardif KD, et al. Among authors: cimbora dm. Mol Cancer Ther. 2011 Dec;10(12):2267-75. doi: 10.1158/1535-7163.MCT-11-0453. Epub 2011 Oct 6. Mol Cancer Ther. 2011. PMID: 21980130
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.
Vijay Kumar D, Hoarau C, Bursavich M, Slattum P, Gerrish D, Yager K, Saunders M, Shenderovich M, Roth BL, McKinnon R, Chan A, Cimbora DM, Bradford C, Reeves L, Patton S, Papac DI, Williams BL, Carlson RO. Vijay Kumar D, et al. Among authors: cimbora dm. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4377-85. doi: 10.1016/j.bmcl.2012.04.131. Epub 2012 May 5. Bioorg Med Chem Lett. 2012. PMID: 22632936
Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.
Kim SH, Bajji A, Tangallapally R, Markovitz B, Trovato R, Shenderovich M, Baichwal V, Bartel P, Cimbora D, McKinnon R, Robinson R, Papac D, Wettstein D, Carlson R, Yager KM. Kim SH, et al. J Med Chem. 2012 Sep 13;55(17):7480-501. doi: 10.1021/jm3004619. Epub 2012 Aug 31. J Med Chem. 2012. PMID: 22913511
Oxindole derivatives as inhibitors of TAK1 kinase.
Lockman JW, Reeder MD, Robinson R, Ormonde PA, Cimbora DM, Williams BL, Willardsen JA. Lockman JW, et al. Among authors: cimbora dm. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1724-7. doi: 10.1016/j.bmcl.2011.01.077. Epub 2011 Jan 26. Bioorg Med Chem Lett. 2011. PMID: 21316225
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
Bursavich MG, Parker DP, Willardsen JA, Gao ZH, Davis T, Ostanin K, Robinson R, Peterson A, Cimbora DM, Zhu JF, Richards B. Bursavich MG, et al. Among authors: cimbora dm. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1677-9. doi: 10.1016/j.bmcl.2010.01.058. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20137940
The protein network of HIV budding.
von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI. von Schwedler UK, et al. Among authors: cimbora dm. Cell. 2003 Sep 19;114(6):701-13. doi: 10.1016/s0092-8674(03)00714-1. Cell. 2003. PMID: 14505570 Free article.
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