Aleksandrov AA - Search Results

1

Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration.

Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. Clunes LA, et al. Among authors: aleksandrov aa. FASEB J. 2012 Feb;26(2):533-45. doi: 10.1096/fj.11-192377. Epub 2011 Oct 11. FASEB J. 2012. PMID: 21990373 Free PMC article.

2

Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.

He L, Kota P, Aleksandrov AA, Cui L, Jensen T, Dokholyan NV, Riordan JR. He L, et al. Among authors: aleksandrov aa. FASEB J. 2013 Feb;27(2):536-45. doi: 10.1096/fj.12-216119. Epub 2012 Oct 26. FASEB J. 2013. PMID: 23104983 Free PMC article.

3

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.

Hegedus T, Aleksandrov A, Cui L, Gentzsch M, Chang XB, Riordan JR. Hegedus T, et al. Biochim Biophys Acta. 2006 May;1758(5):565-72. doi: 10.1016/j.bbamem.2006.03.006. Epub 2006 Mar 31. Biochim Biophys Acta. 2006. PMID: 16624253 Free article.

4

Domain interdependence in the biosynthetic assembly of CFTR.

Cui L, Aleksandrov L, Chang XB, Hou YX, He L, Hegedus T, Gentzsch M, Aleksandrov A, Balch WE, Riordan JR. Cui L, et al. J Mol Biol. 2007 Jan 26;365(4):981-94. doi: 10.1016/j.jmb.2006.10.086. Epub 2006 Nov 10. J Mol Biol. 2007. PMID: 17113596

5

Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2).

Aleksandrov L, Aleksandrov A, Riordan JR. Aleksandrov L, et al. Biochem J. 2008 Nov 15;416(1):129-36. doi: 10.1042/BJ20081068. Biochem J. 2008. PMID: 18605986

6

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.

Hegedus T, Aleksandrov A, Mengos A, Cui L, Jensen TJ, Riordan JR. Hegedus T, et al. Biochim Biophys Acta. 2009 Jun;1788(6):1341-9. doi: 10.1016/j.bbamem.2009.03.015. Epub 2009 Mar 26. Biochim Biophys Acta. 2009. PMID: 19328185 Free article.

7

DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy.

He L, Kennedy AS, Houck S, Aleksandrov A, Quinney NL, Cyr-Scully A, Cholon DM, Gentzsch M, Randell SH, Ren HY, Cyr DM. He L, et al. Mol Biol Cell. 2021 Apr 1;32(7):538-553. doi: 10.1091/mbc.E20-11-0688. Epub 2021 Feb 3. Mol Biol Cell. 2021. PMID: 33534640 Free PMC article.

8

The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.

Cui L, Aleksandrov L, Hou YX, Gentzsch M, Chen JH, Riordan JR, Aleksandrov AA. Cui L, et al. Among authors: aleksandrov l, aleksandrov aa. J Physiol. 2006 Apr 15;572(Pt 2):347-58. doi: 10.1113/jphysiol.2005.099457. Epub 2006 Feb 16. J Physiol. 2006. PMID: 16484308 Free PMC article.

9

CFTR (ABCC7) is a hydrolyzable-ligand-gated channel.

Aleksandrov AA, Aleksandrov LA, Riordan JR. Aleksandrov AA, et al. Among authors: aleksandrov la. Pflugers Arch. 2007 Feb;453(5):693-702. doi: 10.1007/s00424-006-0140-z. Epub 2006 Sep 26. Pflugers Arch. 2007. PMID: 17021796 Review.

10

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.

Serohijos AW, Hegedus T, Aleksandrov AA, He L, Cui L, Dokholyan NV, Riordan JR. Serohijos AW, et al. Among authors: aleksandrov aa. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3256-61. doi: 10.1073/pnas.0800254105. Epub 2008 Feb 27. Proc Natl Acad Sci U S A. 2008. PMID: 18305154 Free PMC article.

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