Cholon D - Search Results

1

Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration.

Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. Clunes LA, et al. Among authors: cholon d. FASEB J. 2012 Feb;26(2):533-45. doi: 10.1096/fj.11-192377. Epub 2011 Oct 11. FASEB J. 2012. PMID: 21990373 Free PMC article.

2

Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures.

Cholon DM, O'Neal WK, Randell SH, Riordan JR, Gentzsch M. Cholon DM, et al. Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L304-14. doi: 10.1152/ajplung.00016.2009. Epub 2009 Dec 11. Am J Physiol Lung Cell Mol Physiol. 2010. PMID: 20008117 Free PMC article.

3

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis.

Cholon DM, Quinney NL, Fulcher ML, Esther CR Jr, Das J, Dokholyan NV, Randell SH, Boucher RC, Gentzsch M. Cholon DM, et al. Sci Transl Med. 2014 Jul 23;6(246):246ra96. doi: 10.1126/scitranslmed.3008680. Sci Transl Med. 2014. PMID: 25101886 Free PMC article.

4

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770.

Gentzsch M, Ren HY, Houck SA, Quinney NL, Cholon DM, Sopha P, Chaudhry IG, Das J, Dokholyan NV, Randell SH, Cyr DM. Gentzsch M, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L550-9. doi: 10.1152/ajplung.00186.2016. Epub 2016 Jul 8. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27402691 Free PMC article.

5

Efficacy of lumacaftor-ivacaftor for the treatment of cystic fibrosis patients homozygous for the F508del-CFTR mutation.

Cholon DM, Esther CR Jr, Gentzsch M. Cholon DM, et al. Expert Rev Precis Med Drug Dev. 2016;1(3):235-243. doi: 10.1080/23808993.2016.1175299. Epub 2016 Apr 22. Expert Rev Precis Med Drug Dev. 2016. PMID: 27482545 Free PMC article.

6

Recent progress in translational cystic fibrosis research using precision medicine strategies.

Cholon DM, Gentzsch M. Cholon DM, et al. J Cyst Fibros. 2018 Mar;17(2S):S52-S60. doi: 10.1016/j.jcf.2017.09.005. Epub 2017 Oct 4. J Cyst Fibros. 2018. PMID: 28986017 Free PMC article. Review.

7

Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.

Tomati V, Caci E, Ferrera L, Pesce E, Sondo E, Cholon DM, Quinney NL, Boyles SE, Armirotti A, Ravazzolo R, Galietta LJ, Gentzsch M, Pedemonte N. Tomati V, et al. JCI Insight. 2018 Feb 8;3(3):e98699. doi: 10.1172/jci.insight.98699. eCollection 2018 Feb 8. JCI Insight. 2018. PMID: 29415893 Free PMC article.

8

The cystic fibrosis airway milieu enhances rescue of F508del in a pre-clinical model.

Gentzsch M, Cholon DM, Quinney NL, Boyles SE, Martino MEB, Ribeiro CMP. Gentzsch M, et al. Eur Respir J. 2018 Dec 20;52(6):1801133. doi: 10.1183/13993003.01133-2018. Print 2018 Dec. Eur Respir J. 2018. PMID: 30287473 Free PMC article. No abstract available.

9

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.

Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. Armirotti A, et al. Among authors: cholon dm. Sci Rep. 2019 Jul 16;9(1):10310. doi: 10.1038/s41598-019-46639-1. Sci Rep. 2019. PMID: 31311979 Free PMC article.

10

Personalised medicine for non-classic cystic fibrosis resulting from rare CFTR mutations.

McCravy MS, Quinney NL, Cholon DM, Boyles SE, Jensen TJ, Aleksandrov AA, Donaldson SH, Noone PG, Gentzsch M. McCravy MS, et al. Among authors: cholon dm. Eur Respir J. 2020 Jul 30;56(1):2000062. doi: 10.1183/13993003.00062-2020. Print 2020 Jul. Eur Respir J. 2020. PMID: 32265312 Free PMC article. No abstract available.

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