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Page 1
Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration.
Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. Clunes LA, et al. Among authors: worthington en. FASEB J. 2012 Feb;26(2):533-45. doi: 10.1096/fj.11-192377. Epub 2011 Oct 11. FASEB J. 2012. PMID: 21990373 Free PMC article.
Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.
Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC. Ehre C, et al. Among authors: worthington en. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16528-33. doi: 10.1073/pnas.1206552109. Epub 2012 Sep 24. Proc Natl Acad Sci U S A. 2012. PMID: 23012413 Free PMC article.
SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel.
Wu T, Goriounova AS, Worthington EN, Wrennall JA, Ghosh A, Ahmad S, Flori Sassano M, Tarran R. Wu T, et al. Among authors: worthington en. Physiol Rep. 2022 May;10(10):e15306. doi: 10.14814/phy2.15306. Physiol Rep. 2022. PMID: 35581745 Free PMC article.
CFTR bearing variant p.Phe312del exhibits function inconsistent with phenotype and negligible response to ivacaftor.
Raraigh KS, Paul KC, Goralski JL, Worthington EN, Faino AV, Sciortino S, Wang Y, Aksit MA, Ling H, Osorio DL, Onchiri FM, Patel SU, Merlo CA, Montemayor K, Gibson RL, West NE, Thakerar A, Bridges RJ, Sheppard DN, Sharma N, Cutting GR. Raraigh KS, et al. Among authors: worthington en. JCI Insight. 2022 Mar 22;7(6):e148841. doi: 10.1172/jci.insight.148841. JCI Insight. 2022. PMID: 35315358 Free PMC article.