Wang H - Search Results

1

Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice.

Li Q, Peng X, Yang H, Wang H, Shu Y. Li Q, et al. Among authors: wang h. Mol Pharm. 2011 Dec 5;8(6):2476-83. doi: 10.1021/mp200395f. Epub 2011 Oct 12. Mol Pharm. 2011. PMID: 21991918 Free PMC article.

2

SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver.

Li L, Li H, Garzel B, Yang H, Sueyoshi T, Li Q, Shu Y, Zhang J, Hu B, Heyward S, Moeller T, Xie W, Negishi M, Wang H. Li L, et al. Among authors: wang h. Mol Pharmacol. 2015 Apr;87(4):674-82. doi: 10.1124/mol.114.097287. Epub 2015 Jan 27. Mol Pharmacol. 2015. PMID: 25628225 Free PMC article.

3

Differential effects of metformin-mediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial.

Metry M, Krug SA, Karra VK, Kane MA, Fink JC, Shu Y, Wang H, Polli JE. Metry M, et al. Among authors: wang h. Clin Transl Sci. 2022 Oct;15(10):2468-2478. doi: 10.1111/cts.13375. Epub 2022 Aug 7. Clin Transl Sci. 2022. PMID: 35899436 Free PMC article. Clinical Trial.

4

Synergistically enhanced CYP2B6 inducibility between a polymorphic mutation in CYP2B6 promoter and pregnane X receptor activation.

Li H, Ferguson SS, Wang H. Li H, et al. Among authors: wang h. Mol Pharmacol. 2010 Oct;78(4):704-13. doi: 10.1124/mol.110.065185. Epub 2010 Jul 12. Mol Pharmacol. 2010. PMID: 20624854 Free PMC article.

5

Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.

Yang H, Garzel B, Heyward S, Moeller T, Shapiro P, Wang H. Yang H, et al. Among authors: wang h. Mol Pharmacol. 2014 Feb;85(2):249-60. doi: 10.1124/mol.113.089763. Epub 2013 Nov 19. Mol Pharmacol. 2014. PMID: 24252946 Free PMC article.

6

The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

Li L, Chen T, Stanton JD, Sueyoshi T, Negishi M, Wang H. Li L, et al. Among authors: wang h. Mol Pharmacol. 2008 Aug;74(2):443-53. doi: 10.1124/mol.108.046656. Epub 2008 May 20. Mol Pharmacol. 2008. PMID: 18492798 Free PMC article.

7

IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.

Wang AJ, Yang Z, Grinchuk V, Smith A, Qin B, Lu N, Wang D, Wang H, Ramalingam TR, Wynn TA, Urban JF Jr, Shea-Donohue T, Zhao A. Wang AJ, et al. Among authors: wang h, wang d. J Immunol. 2015 Nov 15;195(10):4771-80. doi: 10.4049/jimmunol.1500337. Epub 2015 Sep 30. J Immunol. 2015. PMID: 26423151 Free PMC article.

8

Activation of the Constitutive Androstane Receptor Increases the Therapeutic Index of CHOP in Lymphoma Treatment.

Hedrich WD, Xiao J, Heyward S, Zhang Y, Zhang J, Baer MR, Hassan HE, Wang H. Hedrich WD, et al. Among authors: wang h. Mol Cancer Ther. 2016 Mar;15(3):392-401. doi: 10.1158/1535-7163.MCT-15-0667. Epub 2016 Jan 28. Mol Cancer Ther. 2016. PMID: 26823489 Free PMC article.

9

Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor.

Mackowiak B, Li L, Welch MA, Li D, Jones JW, Heyward S, Kane MA, Swaan PW, Wang H. Mackowiak B, et al. Among authors: wang h. Mol Pharmacol. 2017 Jul;92(1):75-87. doi: 10.1124/mol.117.108621. Epub 2017 Apr 25. Mol Pharmacol. 2017. PMID: 28442602 Free PMC article.

10

Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.

Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, Wang H. Li L, et al. Among authors: wang h. Mol Pharmacol. 2019 Sep;96(3):345-354. doi: 10.1124/mol.119.116616. Epub 2019 Jul 10. Mol Pharmacol. 2019. PMID: 31436536 Free PMC article.

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