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Page 1
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P₁ direct agonists.
Aguilar N, Mir M, Grima PM, López M, Segarra V, Esteban L, Moreno I, Godessart N, Tarrasón G, Domenech T, Vilella D, Armengol C, Córdoba M, Sabaté M, Casals D, Domínguez M. Aguilar N, et al. Among authors: segarra v. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7672-6. doi: 10.1016/j.bmcl.2012.09.110. Epub 2012 Oct 11. Bioorg Med Chem Lett. 2012. PMID: 23141913
4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships.
Roberts RS, Sevilla S, Ferrer M, Taltavull J, Hernández B, Segarra V, Gràcia J, Lehner MD, Gavaldà A, Andrés M, Cabedo J, Vilella D, Eichhorn P, Calama E, Carcasona C, Miralpeix M. Roberts RS, et al. Among authors: segarra v. J Med Chem. 2018 Mar 22;61(6):2472-2489. doi: 10.1021/acs.jmedchem.7b01751. Epub 2018 Mar 13. J Med Chem. 2018. PMID: 29502405
1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.
Fernández F, Caamaño O, Isabel Nieto M, López C, García-Mera X, Stefanachi A, Nicolotti O, Isabel Loza M, Brea J, Esteve C, Segarra V, Vidal B, Carotti A. Fernández F, et al. Among authors: segarra v. Bioorg Med Chem. 2009 May 15;17(10):3618-29. doi: 10.1016/j.bmc.2009.03.062. Epub 2009 Apr 5. Bioorg Med Chem. 2009. PMID: 19398343
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Prat M, Buil MA, Fernández MD, Castro J, Monleón JM, Tort L, Casals G, Ferrer M, Huerta JM, Espinosa S, López M, Segarra V, Gavaldà A, Miralpeix M, Ramos I, Vilella D, González M, Córdoba M, Cárdenas A, Antón F, Beleta J, Ryder H. Prat M, et al. Among authors: segarra v. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3457-61. doi: 10.1016/j.bmcl.2011.03.096. Epub 2011 Apr 3. Bioorg Med Chem Lett. 2011. PMID: 21524581
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
Prat M, Buil MA, Fernández MD, Tort L, Monleón JM, Casals G, Ferrer M, Castro J, Gavaldà A, Miralpeix M, Ramos I, Vilella D, Huerta JM, Espinosa S, Hernández B, Segarra V, Córdoba M. Prat M, et al. Among authors: segarra v. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1736-1741. doi: 10.1016/j.bmcl.2015.02.065. Epub 2015 Mar 5. Bioorg Med Chem Lett. 2015. PMID: 25800115
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
Gràcia J, Buil MA, Castro J, Eichhorn P, Ferrer M, Gavaldà A, Hernández B, Segarra V, Lehner MD, Moreno I, Pagès L, Roberts RS, Serrat J, Sevilla S, Taltavull J, Andrés M, Cabedo J, Vilella D, Calama E, Carcasona C, Miralpeix M. Gràcia J, et al. Among authors: segarra v. J Med Chem. 2016 Dec 8;59(23):10479-10497. doi: 10.1021/acs.jmedchem.6b00829. Epub 2016 Nov 17. J Med Chem. 2016. PMID: 27933955
Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.
Orellana A, García-González V, López R, Pascual-Guiral S, Lozoya E, Díaz J, Casals D, Barrena A, Paris S, Andrés M, Segarra V, Vilella D, Malhotra R, Eastwood P, Planagumà A, Miralpeix M, Nueda A. Orellana A, et al. Among authors: segarra v. PLoS One. 2018 Jan 10;13(1):e0189247. doi: 10.1371/journal.pone.0189247. eCollection 2018. PLoS One. 2018. PMID: 29320511 Free PMC article.
95 results