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Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki AM, Gish GD, Cerny-Reiterer S, Koide A, Beug H, Pawson T, Valent P, Koide S, Superti-Furga G. Grebien F, et al. Among authors: hantschel o. Cell. 2011 Oct 14;147(2):306-19. doi: 10.1016/j.cell.2011.08.046. Cell. 2011. PMID: 22000011 Free PMC article.
The druggability of SH2 domains unmasked.
Hantschel O. Hantschel O. Nat Chem Biol. 2024 Mar;20(3):271-272. doi: 10.1038/s41589-024-01557-w. Nat Chem Biol. 2024. PMID: 38361089 No abstract available.
A myristoyl/phosphotyrosine switch regulates c-Abl.
Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G. Hantschel O, et al. Cell. 2003 Mar 21;112(6):845-57. doi: 10.1016/s0092-8674(03)00191-0. Cell. 2003. PMID: 12654250 Free article.
Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J. Nagar B, et al. Among authors: hantschel o. Cell. 2003 Mar 21;112(6):859-71. doi: 10.1016/s0092-8674(03)00194-6. Cell. 2003. PMID: 12654251 Free article.
Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl.
Hantschel O, Wiesner S, Güttler T, Mackereth CD, Rix LL, Mikes Z, Dehne J, Görlich D, Sattler M, Superti-Furga G. Hantschel O, et al. Mol Cell. 2005 Aug 19;19(4):461-73. doi: 10.1016/j.molcel.2005.06.030. Mol Cell. 2005. PMID: 16109371 Free article.
80 results