Chakrapani H - Search Results

1

Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.

Maciag AE, Nandurdikar RS, Hong SY, Chakrapani H, Diwan B, Morris NL, Shami PJ, Shiao YH, Anderson LM, Keefer LK, Saavedra JE. Maciag AE, et al. Among authors: chakrapani h. J Med Chem. 2011 Nov 24;54(22):7751-8. doi: 10.1021/jm2004128. Epub 2011 Oct 28. J Med Chem. 2011. PMID: 22003962 Free PMC article.

2

V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO.

Chakrapani H, Showalter BM, Kong L, Keefer LK, Saavedra JE. Chakrapani H, et al. Org Lett. 2007 Aug 16;9(17):3409-12. doi: 10.1021/ol701419a. Epub 2007 Jul 20. Org Lett. 2007. PMID: 17658755

3

Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.

Chakrapani H, Showalter BM, Citro ML, Keefer LK, Saavedra JE. Chakrapani H, et al. Org Lett. 2007 Oct 25;9(22):4551-4. doi: 10.1021/ol7019636. Epub 2007 Oct 5. Org Lett. 2007. PMID: 17918856

4

Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.

Chakrapani H, Wilde TC, Citro ML, Goodblatt MM, Keefer LK, Saavedra JE. Chakrapani H, et al. Bioorg Med Chem. 2008 Mar 1;16(5):2657-64. doi: 10.1016/j.bmc.2007.11.035. Epub 2007 Nov 17. Bioorg Med Chem. 2008. PMID: 18060792 Free PMC article.

5

Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound.

Chakrapani H, Goodblatt MM, Udupi V, Malaviya S, Shami PJ, Keefer LK, Saavedra JE. Chakrapani H, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3. doi: 10.1016/j.bmcl.2007.12.044. Epub 2008 Jan 4. Bioorg Med Chem Lett. 2008. PMID: 18178089 Free PMC article.

6

Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.

Chakrapani H, Kalathur RC, Maciag AE, Citro ML, Ji X, Keefer LK, Saavedra JE. Chakrapani H, et al. Bioorg Med Chem. 2008 Nov 15;16(22):9764-71. doi: 10.1016/j.bmc.2008.09.063. Epub 2008 Sep 30. Bioorg Med Chem. 2008. PMID: 18930407 Free PMC article.

7

Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs.

Chakrapani H, Maciag AE, Citro ML, Keefer LK, Saavedra JE. Chakrapani H, et al. Org Lett. 2008 Nov 20;10(22):5155-8. doi: 10.1021/ol8020989. Epub 2008 Oct 29. Org Lett. 2008. PMID: 18956868 Free PMC article.

8

Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities.

Andrei D, Maciag AE, Chakrapani H, Citro ML, Keefer LK, Saavedra JE. Andrei D, et al. Among authors: chakrapani h. J Med Chem. 2008 Dec 25;51(24):7944-52. doi: 10.1021/jm800831y. J Med Chem. 2008. PMID: 19053760 Free PMC article.

9

Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.

Nandurdikar RS, Maciag AE, Citro ML, Shami PJ, Keefer LK, Saavedra JE, Chakrapani H. Nandurdikar RS, et al. Among authors: chakrapani h. Bioorg Med Chem Lett. 2009 May 15;19(10):2760-2. doi: 10.1016/j.bmcl.2009.03.115. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19364650 Free PMC article.

10

The nitric oxide prodrug JS-K and its structural analogues as cancer therapeutic agents.

Maciag AE, Saavedra JE, Chakrapani H. Maciag AE, et al. Among authors: chakrapani h. Anticancer Agents Med Chem. 2009 Sep;9(7):798-803. doi: 10.2174/187152009789056949. Epub 2009 Sep 1. Anticancer Agents Med Chem. 2009. PMID: 19538173 Review.

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