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Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.
Malhotra D, Thimmulappa RK, Mercado N, Ito K, Kombairaju P, Kumar S, Ma J, Feller-Kopman D, Wise R, Barnes P, Biswal S. Malhotra D, et al. Among authors: mercado n. J Clin Invest. 2011 Nov;121(11):4289-302. doi: 10.1172/JCI45144. Epub 2011 Oct 17. J Clin Invest. 2011. Retraction in: J Clin Invest. 2014 Dec;124(12):5521. doi: 10.1172/JCI79606 PMID: 22005302 Free PMC article. Retracted.
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, Barnes PJ. Mercado N, et al. Biochem Biophys Res Commun. 2011 Mar 11;406(2):292-8. doi: 10.1016/j.bbrc.2011.02.035. Epub 2011 Feb 12. Biochem Biophys Res Commun. 2011. PMID: 21320471 Free PMC article.
146 results