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Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression.
Ranjitkar S, Jones AK, Mostafavi M, Zwirko Z, Iartchouk O, Barnes SW, Walker JR, Willis TW, Lee PS, Dean CR. Ranjitkar S, et al. Among authors: walker jr. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01718-18. doi: 10.1128/AAC.01718-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30420483 Free PMC article.
Defects in Efflux (oprM), β-Lactamase (ampC), and Lipopolysaccharide Transport (lptE) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61.
Shen X, Johnson NV, Kreamer NNK, Barnes SW, Walker JR, Woods AL, Six DA, Dean CR. Shen X, et al. Among authors: walker jr. Antimicrob Agents Chemother. 2019 Jun 24;63(7):e00784-19. doi: 10.1128/AAC.00784-19. Print 2019 Jul. Antimicrob Agents Chemother. 2019. PMID: 31036686 Free PMC article.
Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms.
Jones AK, Caughlan RE, Woods AL, Uehara K, Xie L, Barnes SW, Walker JR, Thompson KV, Ranjitkar S, Lee PS, Dean CR. Jones AK, et al. Among authors: walker jr. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01490-19. doi: 10.1128/AAC.01490-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31658970 Free PMC article.
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE 3rd, Boshoff HI. Tahlan K, et al. Among authors: walker jr. Antimicrob Agents Chemother. 2012 Apr;56(4):1797-809. doi: 10.1128/AAC.05708-11. Epub 2012 Jan 17. Antimicrob Agents Chemother. 2012. PMID: 22252828 Free PMC article.
Identification of elongation factor G as the conserved cellular target of argyrin B.
Nyfeler B, Hoepfner D, Palestrant D, Kirby CA, Whitehead L, Yu R, Deng G, Caughlan RE, Woods AL, Jones AK, Barnes SW, Walker JR, Gaulis S, Hauy E, Brachmann SM, Krastel P, Studer C, Riedl R, Estoppey D, Aust T, Movva NR, Wang Z, Salcius M, Michaud GA, McAllister G, Murphy LO, Tallarico JA, Wilson CJ, Dean CR. Nyfeler B, et al. Among authors: walker jr. PLoS One. 2012;7(9):e42657. doi: 10.1371/journal.pone.0042657. Epub 2012 Sep 10. PLoS One. 2012. PMID: 22970117 Free PMC article.
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, van de Vegte-Bolmer M, van Gemert GJ, Wirjanata G, Sebayang B, Marfurt J, Russell B, Suwanarusk R, Price RN, Nosten F, Tungtaeng A, Gettayacamin M, Sattabongkot J, Taylor J, Walker JR, Tully D, Patra KP, Flannery EL, Vinetz JM, Renia L, Sauerwein RW, Winzeler EA, Glynne RJ, Diagana TT. Kuhen KL, et al. Among authors: walker jr. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7. doi: 10.1128/AAC.02727-13. Epub 2014 Jun 9. Antimicrob Agents Chemother. 2014. PMID: 24913172 Free PMC article.
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D. Wilson R, et al. Among authors: walker jr. Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16. Nat Chem Biol. 2013. PMID: 23770708 Free PMC article.
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F. Khare S, et al. Among authors: walker jr. PLoS Pathog. 2015 Jul 17;11(7):e1005058. doi: 10.1371/journal.ppat.1005058. eCollection 2015 Jul. PLoS Pathog. 2015. PMID: 26186534 Free PMC article.
1,060 results