Gadd MS - Search Results

1

Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM. Gadd MS, et al. J Biol Chem. 2011 Dec 16;286(50):42971-80. doi: 10.1074/jbc.M111.248559. Epub 2011 Oct 24. J Biol Chem. 2011. PMID: 22025611 Free PMC article.

2

Crystallization and diffraction of an Lhx4-Isl2 complex.

Gadd MS, Langley DB, Guss JM, Matthews JM. Gadd MS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):151-3. doi: 10.1107/S1744309108043431. Epub 2009 Jan 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19194008 Free PMC article.

3

Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

Bhati M, Lee C, Gadd MS, Jeffries CM, Kwan A, Whitten AE, Trewhella J, Mackay JP, Matthews JM. Bhati M, et al. Among authors: gadd ms. PLoS One. 2012;7(7):e40719. doi: 10.1371/journal.pone.0040719. Epub 2012 Jul 25. PLoS One. 2012. PMID: 22848397 Free PMC article.

4

Crystallization and diffraction of an Isl1-Ldb1 complex.

Gadd MS, Jacques DA, Guss JM, Matthews JM. Gadd MS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1398-401. doi: 10.1107/S1744309112040031. Epub 2012 Oct 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 23143258 Free PMC article.

5

A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

Gadd MS, Jacques DA, Nisevic I, Craig VJ, Kwan AH, Guss JM, Matthews JM. Gadd MS, et al. J Biol Chem. 2013 Jul 26;288(30):21924-35. doi: 10.1074/jbc.M113.478586. Epub 2013 Jun 9. J Biol Chem. 2013. PMID: 23750000 Free PMC article.

6

Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes.

Fung HK, Gadd MS, Drury TA, Cheung S, Guss JM, Coleman NV, Matthews JM. Fung HK, et al. Among authors: gadd ms. Mol Microbiol. 2015 Aug;97(3):439-53. doi: 10.1111/mmi.13039. Epub 2015 May 20. Mol Microbiol. 2015. PMID: 25899475 Free article.

7

Structural basis of PROTAC cooperative recognition for selective protein degradation.

Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle M, Ciulli A. Gadd MS, et al. Nat Chem Biol. 2017 May;13(5):514-521. doi: 10.1038/nchembio.2329. Epub 2017 Mar 13. Nat Chem Biol. 2017. PMID: 28288108 Free PMC article.

8

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.

Galdeano C, Gadd MS, Soares P, Scaffidi S, Van Molle I, Birced I, Hewitt S, Dias DM, Ciulli A. Galdeano C, et al. Among authors: gadd ms. J Med Chem. 2014 Oct 23;57(20):8657-63. doi: 10.1021/jm5011258. Epub 2014 Oct 6. J Med Chem. 2014. PMID: 25166285 Free PMC article.

9

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.

Frost J, Galdeano C, Soares P, Gadd MS, Grzes KM, Ellis L, Epemolu O, Shimamura S, Bantscheff M, Grandi P, Read KD, Cantrell DA, Rocha S, Ciulli A. Frost J, et al. Among authors: gadd ms. Nat Commun. 2016 Nov 4;7:13312. doi: 10.1038/ncomms13312. Nat Commun. 2016. PMID: 27811928 Free PMC article.

10

Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.

Cardote TAF, Gadd MS, Ciulli A. Cardote TAF, et al. Among authors: gadd ms. Structure. 2017 Jun 6;25(6):901-911.e3. doi: 10.1016/j.str.2017.04.009. Structure. 2017. PMID: 28591624 Free PMC article.

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