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Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist.
Ismail S, Dubois-Vedrenne I, Laval M, Tikhonova IG, D'Angelo R, Sanchez C, Clerc P, Gherardi MJ, Gigoux V, Magnan R, Fourmy D. Ismail S, et al. Among authors: fourmy d, d angelo r. Mol Cell Endocrinol. 2015 Oct 15;414:202-15. doi: 10.1016/j.mce.2015.07.001. Epub 2015 Jul 28. Mol Cell Endocrinol. 2015. PMID: 26225752
The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process.
Escrieut C, Gigoux V, Archer E, Verrier S, Maigret B, Behrendt R, Moroder L, Bignon E, Silvente-Poirot S, Pradayrol L, Fourmy D. Escrieut C, et al. Among authors: fourmy d. J Biol Chem. 2002 Mar 1;277(9):7546-55. doi: 10.1074/jbc.M108563200. Epub 2001 Nov 27. J Biol Chem. 2002. PMID: 11724786 Free article.
Identification of putative amino acids of the CCK1R binding site was achieved by dynamics-based docking of the ligand CCK in a refined three-dimensional model of the CCK1R using, as constraints, previous results that identified contact points between residues of CCK and CCK1R (Ke …
Identification of putative amino acids of the CCK1R binding site was achieved by dynamics-based docking of the ligand CCK in a refined three …
Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.
Galés C, Poirot M, Taillefer J, Maigret B, Martinez J, Moroder L, Escrieut C, Pradayrol L, Fourmy D, Silvente-Poirot S. Galés C, et al. Among authors: fourmy d. Mol Pharmacol. 2003 May;63(5):973-82. doi: 10.1124/mol.63.5.973. Mol Pharmacol. 2003. PMID: 12695525
Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice.
Clerc P, Coll Constans MG, Lulka H, Broussaud S, Guigné C, Leung-Theung-Long S, Perrin C, Knauf C, Carpéné C, Pénicaud L, Seva C, Burcelin R, Valet P, Fourmy D, Dufresne M. Clerc P, et al. Among authors: fourmy d. Endocrinology. 2007 Mar;148(3):1039-49. doi: 10.1210/en.2006-1064. Epub 2006 Nov 22. Endocrinology. 2007. PMID: 17122076
174 results