Broo A - Search Results

1

Discovery, optimisation and in vivo evaluation of novel GPR119 agonists.

Brocklehurst KJ, Broo A, Butlin RJ, Brown HS, Clarke DS, Davidsson Ö, Goldberg K, Groombridge SD, Kelly EE, Leach A, McKerrecher D, O'Donnell C, Poucher S, Schofield P, Scott JS, Teague J, Westgate L, Wood MJ. Brocklehurst KJ, et al. Among authors: broo a. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7310-6. doi: 10.1016/j.bmcl.2011.10.033. Epub 2011 Oct 18. Bioorg Med Chem Lett. 2011. PMID: 22061639

2

Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.

Scott JS, Birch AM, Brocklehurst KJ, Broo A, Brown HS, Butlin RJ, Clarke DS, Davidsson O, Ertan A, Goldberg K, Groombridge SD, Hudson JA, Laber D, Leach AG, Macfaul PA, McKerrecher D, Pickup A, Schofield P, Svensson PH, Sörme P, Teague J. Scott JS, et al. Among authors: broo a. J Med Chem. 2012 Jun 14;55(11):5361-79. doi: 10.1021/jm300310c. Epub 2012 May 17. J Med Chem. 2012. PMID: 22545772

3

Prediction of drug candidates' sensitivity toward autoxidation: computational estimation of C-H dissociation energies of carbon-centered radicals.

Andersson T, Broo A, Evertsson E. Andersson T, et al. Among authors: broo a. J Pharm Sci. 2014 Jul;103(7):1949-1955. doi: 10.1002/jps.23986. Epub 2014 May 13. J Pharm Sci. 2014. PMID: 24823496

4

Developing an injectable co-formulation of two antidiabetic drugs: Excipient impact on peptide aggregation and pharmacokinetic properties.

Lainé AL, Houvenagel S, Broo A, Jones I, Goodman J, Corkill D, Rose J, Coward S, Sandinge AS, Petrone M, Jermutus L, Santos ALGD. Lainé AL, et al. Among authors: broo a. Int J Pharm. 2020 Feb 25;576:119019. doi: 10.1016/j.ijpharm.2020.119019. Epub 2020 Jan 3. Int J Pharm. 2020. PMID: 31911116

5

A qualitative method for prediction of amine oxidation in methanol and water.

Bäcktorp C, Örnskov E, Evertsson E, Remmelgas J, Broo A. Bäcktorp C, et al. Among authors: broo a. J Pharm Sci. 2015 Apr;104(4):1409-20. doi: 10.1002/jps.24347. Epub 2015 Feb 24. J Pharm Sci. 2015. PMID: 25712623

6

Experimental and Quantum Chemical Evaluations of Pyridine Oxidation Under Drug Development Stress Test Conditions.

Bäcktorp C, Örnskov E, Ottosson J, Evertsson E, Remmelgas J, Broo A. Bäcktorp C, et al. Among authors: broo a. J Pharm Sci. 2015 Dec;104(12):4355-4364. doi: 10.1002/jps.24685. Epub 2015 Nov 2. J Pharm Sci. 2015. PMID: 26523412

7

State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.

Afzelius L, Arnby CH, Broo A, Carlsson L, Isaksson C, Jurva U, Kjellander B, Kolmodin K, Nilsson K, Raubacher F, Weidolf L. Afzelius L, et al. Among authors: broo a. Drug Metab Rev. 2007;39(1):61-86. doi: 10.1080/03602530600969374. Drug Metab Rev. 2007. PMID: 17364881

8

Transferable force field for crystal structure predictions, investigation of performance and exploration of different rescoring strategies using DFT-D methods.

Broo A, Nilsson Lill SO. Broo A, et al. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2016 Aug 1;72(Pt 4):460-76. doi: 10.1107/S2052520616006831. Epub 2016 Jul 16. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2016. PMID: 27484369

9

Does Z' equal 1 or 2? Enhanced powder NMR crystallography verification of a disordered room temperature crystal structure of a p38 inhibitor for chronic obstructive pulmonary disease.

Widdifield CM, Nilsson Lill SO, Broo A, Lindkvist M, Pettersen A, Svensk Ankarberg A, Aldred P, Schantz S, Emsley L. Widdifield CM, et al. Among authors: broo a. Phys Chem Chem Phys. 2017 Jun 28;19(25):16650-16661. doi: 10.1039/c7cp02349a. Phys Chem Chem Phys. 2017. PMID: 28621371

10

Solubility prediction from first principles: a density of states approach.

Boothroyd S , Kerridge A , Broo A , Buttar D , Anwar J . Boothroyd S , et al. Among authors: broo a. Phys Chem Chem Phys. 2018 Aug 15;20(32):20981-20987. doi: 10.1039/c8cp01786g. Phys Chem Chem Phys. 2018. PMID: 30070281

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