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Identifying the proteins to which small-molecule probes and drugs bind in cells.
Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA. Ong SE, et al. Among authors: schreiber sl. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. doi: 10.1073/pnas.0900191106. Epub 2009 Mar 2. Proc Natl Acad Sci U S A. 2009. PMID: 19255428 Free PMC article.
Empirical Bayes analysis of quantitative proteomics experiments.
Margolin AA, Ong SE, Schenone M, Gould R, Schreiber SL, Carr SA, Golub TR. Margolin AA, et al. Among authors: schreiber sl. PLoS One. 2009 Oct 14;4(10):e7454. doi: 10.1371/journal.pone.0007454. PLoS One. 2009. PMID: 19829701 Free PMC article.
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Bradner JE, et al. Among authors: schreiber sl. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12617-22. doi: 10.1073/pnas.1006774107. Epub 2010 Jun 28. Proc Natl Acad Sci U S A. 2010. PMID: 20616024 Free PMC article.
Organic synthesis toward small-molecule probes and drugs.
Schreiber SL. Schreiber SL. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6699-702. doi: 10.1073/pnas.1103205108. Epub 2011 Apr 4. Proc Natl Acad Sci U S A. 2011. PMID: 21464328 Free PMC article. Review.
This perspective article frames the research described in the special issue but also explores how these modern capabilities can both foster a new and more extensive view of basic research in the academy and promote the linkage of life-science research to the discovery of novel ty …
This perspective article frames the research described in the special issue but also explores how these modern capabilities can both foster …
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Raj L, et al. Among authors: schreiber sl. Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. Nature. 2011. Retraction in: Nature. 2018 Sep;561(7723):420. doi: 10.1038/s41586-018-0284-y PMID: 21753854 Free PMC article. Retracted.
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. Kuai L, et al. Among authors: schreiber sl. Chem Biol. 2011 Jul 29;18(7):891-906. doi: 10.1016/j.chembiol.2011.03.017. Chem Biol. 2011. PMID: 21802010 Free PMC article.
557 results