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IFN-α and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells.
Le Buanec H, Gougeon ML, Mathian A, Lebon P, Dupont JM, Peltre G, Hemon P, Schmid M, Bizzini B, Künding T, Burny A, Bensussan A, Amoura Z, Gallo RC, Zagury D. Le Buanec H, et al. Among authors: hemon p. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18995-9000. doi: 10.1073/pnas.1113301108. Epub 2011 Nov 7. Proc Natl Acad Sci U S A. 2011. PMID: 22065791 Free PMC article.
CD8+ tissue-resident memory T cells are expanded in primary Sjögren's disease and can be therapeutically targeted by CD103 blockade.
Mauro D, Lin X, Pontarini E, Wehr P, Guggino G, Tang Y, Deng C, Gandolfo S, Xiao F, Rui K, Huang E, Tian J, Raimondo S, Rischmueller M, Boroky J, Downie-Doyle S, Nel H, Baz-Morelli A, Hsu A, Maraskovsky E, Barr A, Hemon P, Chatzis L, Boschetti CE, Colella G, Alessandro R, Rizzo A, Pers JO, Bombardieri M, Thomas R, Lu L, Ciccia F. Mauro D, et al. Among authors: hemon p. Ann Rheum Dis. 2024 Sep 30;83(10):1345-1357. doi: 10.1136/ard-2023-225069. Ann Rheum Dis. 2024. PMID: 38777379
High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome.
Desvaux E, Hemon P, Soret P, Le Dantec C, Chatzis L, Cornec D, Devauchelle-Pensec V; PRECISESADS clinical consortium; Elouej S, Duguet F, Laigle L, Poirier N, Moingeon P, Bretin S, Pers JO. Desvaux E, et al. Among authors: hemon p. J Autoimmun. 2024 Dec;149:103147. doi: 10.1016/j.jaut.2023.103147. Epub 2023 Dec 18. J Autoimmun. 2024. PMID: 38114349
55 results