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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O. Levy D, et al. Among authors: espejo a. Nat Immunol. 2011 Jan;12(1):29-36. doi: 10.1038/ni.1968. Epub 2010 Dec 5. Nat Immunol. 2011. PMID: 21131967 Free PMC article.
p53 is regulated by the lysine demethylase LSD1.
Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. Huang J, et al. Among authors: espejo ab. Nature. 2007 Sep 6;449(7158):105-8. doi: 10.1038/nature06092. Nature. 2007. PMID: 17805299
Tudor, MBT and chromo domains gauge the degree of lysine methylation.
Kim J, Daniel J, Espejo A, Lake A, Krishna M, Xia L, Zhang Y, Bedford MT. Kim J, et al. Among authors: espejo a. EMBO Rep. 2006 Apr;7(4):397-403. doi: 10.1038/sj.embor.7400625. Epub 2006 Jan 13. EMBO Rep. 2006. PMID: 16415788 Free PMC article.
Protein-domain microarrays.
Espejo A, Bedford MT. Espejo A, et al. Methods Mol Biol. 2004;264:173-81. doi: 10.1385/1-59259-759-9:173. Methods Mol Biol. 2004. PMID: 15020789
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.
Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R. Metzger E, et al. Among authors: espejo a. Nat Struct Mol Biol. 2016 Feb;23(2):132-9. doi: 10.1038/nsmb.3153. Epub 2016 Jan 11. Nat Struct Mol Biol. 2016. PMID: 26751641
Methylation by Set9 modulates FoxO3 stability and transcriptional activity.
Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Calnan DR, et al. Among authors: espejo a. Aging (Albany NY). 2012 Jul;4(7):462-79. doi: 10.18632/aging.100471. Aging (Albany NY). 2012. PMID: 22820736 Free PMC article.
76 results