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Modification of olivomycin A at the side chain of the aglycon yields the derivative with perspective antitumor characteristics.
Tevyashova AN, Shtil AA, Olsufyeva EN, Luzikov YN, Reznikova MI, Dezhenkova LG, Isakova EB, Bukhman VM, Durandin NA, Vinogradov AM, Kuzmin VA, Preobrazhenskaya MN. Tevyashova AN, et al. Among authors: luzikov yn. Bioorg Med Chem. 2011 Dec 15;19(24):7387-93. doi: 10.1016/j.bmc.2011.10.055. Epub 2011 Oct 25. Bioorg Med Chem. 2011. PMID: 22088308
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.
Shchekotikhin AE, Dezhenkova LG, Tsvetkov VB, Luzikov YN, Volodina YL, Tatarskiy VV Jr, Kalinina AA, Treshalin MI, Treshalina HM, Romanenko VI, Kaluzhny DN, Kubbutat M, Schols D, Pommier Y, Shtil AA, Preobrazhenskaya MN. Shchekotikhin AE, et al. Among authors: luzikov yn. Eur J Med Chem. 2016 Apr 13;112:114-129. doi: 10.1016/j.ejmech.2016.01.050. Epub 2016 Feb 4. Eur J Med Chem. 2016. PMID: 26890118 Free PMC article.
Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones.
Shchekotikhin AE, Glazunova VA, Dezhenkova LG, Luzikov YN, Buyanov VN, Treshalina HM, Lesnaya NA, Romanenko VI, Kaluzhny DN, Balzarini J, Agama K, Pommier Y, Shtil AA, Preobrazhenskaya MN. Shchekotikhin AE, et al. Among authors: luzikov yn. Eur J Med Chem. 2014 Oct 30;86:797-805. doi: 10.1016/j.ejmech.2014.09.021. Epub 2014 Sep 8. Eur J Med Chem. 2014. PMID: 25244612
Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties.
Ilyinsky NS, Shchyolkina AK, Borisova OF, Mamaeva OK, Zvereva MI, Azhibek DM, Livshits MA, Mitkevich VA, Balzarini J, Sinkevich YB, Luzikov YN, Dezhenkova LG, Kolotova ES, Shtil AA, Shchekotikhin AE, Kaluzhny DN. Ilyinsky NS, et al. Among authors: luzikov yn. Eur J Med Chem. 2014 Oct 6;85:605-14. doi: 10.1016/j.ejmech.2014.08.030. Epub 2014 Aug 8. Eur J Med Chem. 2014. PMID: 25127152
Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones.
Shchekotikhin AE, Glazunova VA, Dezhenkova LG, Luzikov YN, Sinkevich YB, Kovalenko LV, Buyanov VN, Balzarini J, Huang FC, Lin JJ, Huang HS, Shtil AA, Preobrazhenskaya MN. Shchekotikhin AE, et al. Among authors: luzikov yn. Bioorg Med Chem. 2009 Mar 1;17(5):1861-9. doi: 10.1016/j.bmc.2009.01.047. Epub 2009 Jan 27. Bioorg Med Chem. 2009. PMID: 19208482
Chemical modification and biological evaluation of new semisynthetic derivatives of 28,29-Didehydronystatin A1 (S44HP), a genetically engineered antifungal polyene macrolide antibiotic.
Preobrazhenskaya MN, Olsufyeva EN, Solovieva SE, Tevyashova AN, Reznikova MI, Luzikov YN, Terekhova LP, Trenin AS, Galatenko OA, Treshalin ID, Mirchink EP, Bukhman VM, Sletta H, Zotchev SB. Preobrazhenskaya MN, et al. Among authors: luzikov yn. J Med Chem. 2009 Jan 8;52(1):189-96. doi: 10.1021/jm800695k. J Med Chem. 2009. PMID: 19055412
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.
Danilenko VN, Simonov AY, Lakatosh SA, Kubbutat MH, Totzke F, Schächtele C, Elizarov SM, Bekker OB, Printsevskaya SS, Luzikov YN, Reznikova MI, Shtil AA, Preobrazhenskaya MN. Danilenko VN, et al. Among authors: luzikov yn. J Med Chem. 2008 Dec 25;51(24):7731-6. doi: 10.1021/jm800758s. J Med Chem. 2008. PMID: 19053831
13 results