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Is the oxidative stress theory of aging dead?
Pérez VI, Bokov A, Van Remmen H, Mele J, Ran Q, Ikeno Y, Richardson A. Pérez VI, et al. Biochim Biophys Acta. 2009 Oct;1790(10):1005-14. doi: 10.1016/j.bbagen.2009.06.003. Epub 2009 Jun 11. Biochim Biophys Acta. 2009. PMID: 19524016 Free PMC article. Review.
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.
Zhang Y, Ikeno Y, Qi W, Chaudhuri A, Li Y, Bokov A, Thorpe SR, Baynes JW, Epstein C, Richardson A, Van Remmen H. Zhang Y, et al. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20. doi: 10.1093/gerona/glp132. Epub 2009 Sep 23. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19776219 Free PMC article.
Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.
Pérez VI, Cortez LA, Lew CM, Rodriguez M, Webb CR, Van Remmen H, Chaudhuri A, Qi W, Lee S, Bokov A, Fok W, Jones D, Richardson A, Yodoi J, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y. Pérez VI, et al. J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1286-99. doi: 10.1093/gerona/glr125. Epub 2011 Aug 26. J Gerontol A Biol Sci Med Sci. 2011. PMID: 21873593 Free PMC article.
Rapamycin extends life and health in C57BL/6 mice.
Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Réndon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K. Zhang Y, et al. J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):119-30. doi: 10.1093/gerona/glt056. Epub 2013 May 16. J Gerontol A Biol Sci Med Sci. 2014. PMID: 23682161 Free PMC article.
36 results