Harriman S - Search Results

1

In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase.

Kamel A, Colizza K, Gunduz M, Harriman S, Obach RS. Kamel A, et al. Among authors: harriman s. Xenobiotica. 2012 Apr;42(4):355-62. doi: 10.3109/00498254.2011.630490. Epub 2011 Nov 22. Xenobiotica. 2012. PMID: 22106962

2

Oxidative ipso substitution of 2,4-difluoro-benzylphthalazines: identification of a rare stable quinone methide and subsequent GSH conjugate.

Gunduz M, Argikar UA, Kamel A, Colizza K, Bushee JL, Cirello A, Lombardo F, Harriman S. Gunduz M, et al. Among authors: harriman s. Drug Metab Dispos. 2012 Nov;40(11):2074-80. doi: 10.1124/dmd.112.046268. Epub 2012 Jul 30. Drug Metab Dispos. 2012. PMID: 22851614

3

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state.

Lombardo F, Waters NJ, Argikar UA, Dennehy MK, Zhan J, Gunduz M, Harriman SP, Berellini G, Rajlic IL, Obach RS. Lombardo F, et al. J Clin Pharmacol. 2013 Feb;53(2):167-77. doi: 10.1177/0091270012440281. Epub 2013 Jan 24. J Clin Pharmacol. 2013. PMID: 23436262

4

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.

Lombardo F, Waters NJ, Argikar UA, Dennehy MK, Zhan J, Gunduz M, Harriman SP, Berellini G, Liric Rajlic I, Obach RS. Lombardo F, et al. J Clin Pharmacol. 2013 Feb;53(2):178-91. doi: 10.1177/0091270012440282. Epub 2013 Jan 24. J Clin Pharmacol. 2013. PMID: 23436263

5

Identification of a novel N-carbamoyl glucuronide: in vitro, in vivo, and mechanistic studies.

Gunduz M, Argikar UA, Baeschlin D, Ferreira S, Hosagrahara V, Harriman S. Gunduz M, et al. Among authors: harriman s. Drug Metab Dispos. 2010 Mar;38(3):361-7. doi: 10.1124/dmd.109.030650. Epub 2009 Dec 11. Drug Metab Dispos. 2010. PMID: 20008038

6

A comprehensive listing of bioactivation pathways of organic functional groups.

Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, O'Donnell JP, Boer J, Harriman SP. Kalgutkar AS, et al. Among authors: harriman sp. Curr Drug Metab. 2005 Jun;6(3):161-225. doi: 10.2174/1389200054021799. Curr Drug Metab. 2005. PMID: 15975040 Review.

7

Inhibition of cytochrome P450 enzymes and biochemical aspects of mechanism-based inactivation (MBI).

Kamel A, Harriman S. Kamel A, et al. Among authors: harriman s. Drug Discov Today Technol. 2013 Spring;10(1):e177-89. doi: 10.1016/j.ddtec.2012.09.011. Drug Discov Today Technol. 2013. PMID: 24050247 Review.

8

Identification of saturated and unsaturated fatty acids released during microsomal incubations.

Bushee JL, Liang G, Dunne CE, Harriman SP, Argikar UA. Bushee JL, et al. Xenobiotica. 2014 Aug;44(8):687-95. doi: 10.3109/00498254.2014.884253. Epub 2014 Feb 6. Xenobiotica. 2014. PMID: 24502389

9

Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.

Beebe JS, Jani JP, Knauth E, Goodwin P, Higdon C, Rossi AM, Emerson E, Finkelstein M, Floyd E, Harriman S, Atherton J, Hillerman S, Soderstrom C, Kou K, Gant T, Noe MC, Foster B, Rastinejad F, Marx MA, Schaeffer T, Whalen PM, Roberts WG. Beebe JS, et al. Among authors: harriman s. Cancer Res. 2003 Nov 1;63(21):7301-9. Cancer Res. 2003. PMID: 14612527

10

Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor.

Jani JP, Finn RS, Campbell M, Coleman KG, Connell RD, Currier N, Emerson EO, Floyd E, Harriman S, Kath JC, Morris J, Moyer JD, Pustilnik LR, Rafidi K, Ralston S, Rossi AM, Steyn SJ, Wagner L, Winter SM, Bhattacharya SK. Jani JP, et al. Among authors: harriman s. Cancer Res. 2007 Oct 15;67(20):9887-93. doi: 10.1158/0008-5472.CAN-06-3559. Cancer Res. 2007. PMID: 17942920

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