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Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death.
Rogers HA, Kilday JP, Mayne C, Ward J, Adamowicz-Brice M, Schwalbe EC, Clifford SC, Coyle B, Grundy RG. Rogers HA, et al. Among authors: kilday jp. Acta Neuropathol. 2012 May;123(5):711-25. doi: 10.1007/s00401-011-0904-1. Epub 2011 Nov 23. Acta Neuropathol. 2012. PMID: 22109108 Free PMC article.
Pediatric ependymoma: biological perspectives.
Kilday JP, Rahman R, Dyer S, Ridley L, Lowe J, Coyle B, Grundy R. Kilday JP, et al. Mol Cancer Res. 2009 Jun;7(6):765-86. doi: 10.1158/1541-7786.MCR-08-0584. Epub 2009 Jun 16. Mol Cancer Res. 2009. PMID: 19531565 Review.
Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.
Jeyapalan JN, Noor DA, Lee SH, Tan CL, Appleby VA, Kilday JP, Palmer RD, Schwalbe EC, Clifford SC, Walker DA, Murray MJ, Coleman N, Nicholson JC, Scotting PJ. Jeyapalan JN, et al. Among authors: kilday jp. Br J Cancer. 2011 Aug 9;105(4):575-85. doi: 10.1038/bjc.2011.218. Epub 2011 Jun 28. Br J Cancer. 2011. PMID: 21712824 Free PMC article.
Copy number gain of 1q25 predicts poor progression-free survival for pediatric intracranial ependymomas and enables patient risk stratification: a prospective European clinical trial cohort analysis on behalf of the Children's Cancer Leukaemia Group (CCLG), Societe Francaise d'Oncologie Pediatrique (SFOP), and International Society for Pediatric Oncology (SIOP).
Kilday JP, Mitra B, Domerg C, Ward J, Andreiuolo F, Osteso-Ibanez T, Mauguen A, Varlet P, Le Deley MC, Lowe J, Ellison DW, Gilbertson RJ, Coyle B, Grill J, Grundy RG. Kilday JP, et al. Clin Cancer Res. 2012 Apr 1;18(7):2001-11. doi: 10.1158/1078-0432.CCR-11-2489. Epub 2012 Feb 14. Clin Cancer Res. 2012. PMID: 22338015
Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types.
Schwalbe EC, Hayden JT, Rogers HA, Miller S, Lindsey JC, Hill RM, Nicholson SL, Kilday JP, Adamowicz-Brice M, Storer L, Jacques TS, Robson K, Lowe J, Williamson D, Grundy RG, Bailey S, Clifford SC. Schwalbe EC, et al. Among authors: kilday jp. Acta Neuropathol. 2013 Dec;126(6):943-6. doi: 10.1007/s00401-013-1206-6. Epub 2013 Nov 9. Acta Neuropathol. 2013. PMID: 24212602 Free PMC article. No abstract available.
A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.
Somers J, Wilson LA, Kilday JP, Horvilleur E, Cannell IG, Pöyry TA, Cobbold LC, Kondrashov A, Knight JR, Puget S, Grill J, Grundy RG, Bushell M, Willis AE. Somers J, et al. Among authors: kilday jp. Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115. Epub 2015 Sep 3. Genes Dev. 2015. PMID: 26338418 Free PMC article.
Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours.
Nailor A, Walker DA, Jacques TS, Warren KE, Brem H, Kearns PR, Greenwood J, Penny JI, Pilkington GJ, Carcaboso AM, Fleischhack G, Macarthur D, Slavc I, Meijer L, Gill S, Lowis S, van Vuurden DG, Pearl MS, Clifford SC, Morrissy S, Ivanov DP, Beccaria K, Gilbertson RJ, Straathof K, Green JJ, Smith S, Rahman R, Kilday JP. Nailor A, et al. Among authors: kilday jp. Ecancermedicalscience. 2016 Mar 31;10:630. doi: 10.3332/ecancer.2016.630. eCollection 2016. Ecancermedicalscience. 2016. PMID: 27110286 Free PMC article.
Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification.
Andreiuolo F, Le Teuff G, Bayar MA, Kilday JP, Pietsch T, von Bueren AO, Witt H, Korshunov A, Modena P, Pfister SM, Pagès M, Castel D, Giangaspero F, Chimelli L, Varlet P, Rutkowski S, Frappaz D, Massimino M, Grundy R, Grill J; SIOP Ependymoma Biology Working Group BIOMECA (BIOlogical Markers for Ependymomas in Children and Adolescents). Andreiuolo F, et al. Among authors: kilday jp. PLoS One. 2017 Jun 15;12(6):e0178351. doi: 10.1371/journal.pone.0178351. eCollection 2017. PLoS One. 2017. PMID: 28617804 Free PMC article.
43 results