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Heparin and heparan sulfate disaccharides bind to the exchanger inhibitor peptide region of Na+/Ca2+ exchanger and reduce the cytosolic calcium of smooth muscle cell lines. Requirement of C4-C5 unsaturation and 1--> 4 glycosidic linkage for activity.
Shinjo SK, Tersariol IL, Oliveira V, Nakaie CR, Oshiro ME, Ferreira AT, Santos IA, Dietrich CP, Nader HB. Shinjo SK, et al. Among authors: dietrich cp. J Biol Chem. 2002 Dec 13;277(50):48227-33. doi: 10.1074/jbc.M205867200. Epub 2002 Oct 8. J Biol Chem. 2002. PMID: 12374809 Free article.
Heparan sulfate and cell division.
Porcionatto MA, Nader HB, Dietrich CP. Porcionatto MA, et al. Among authors: dietrich cp. Braz J Med Biol Res. 1999 May;32(5):539-44. doi: 10.1590/s0100-879x1999000500006. Braz J Med Biol Res. 1999. PMID: 10412564 Free article.
New insights on the specificity of heparin and heparan sulfate lyases from Flavobacterium heparinum revealed by the use of synthetic derivatives of K5 polysaccharide from E. coli and 2-O-desulfated heparin.
Nader HB, Kobayashi EY, Chavante SF, Tersariol IL, Castro RA, Shinjo SK, Naggi A, Torri G, Casu B, Dietrich CP. Nader HB, et al. Among authors: dietrich cp. Glycoconj J. 1999 Jun;16(6):265-70. doi: 10.1023/a:1007057826179. Glycoconj J. 1999. PMID: 10579695
188 results