Omura S - Search Results

1

Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line.

Otsu K, Ishinaga H, Suzuki S, Sugawara A, Sunazuka T, Omura S, Jono H, Takeuchi K. Otsu K, et al. Among authors: omura s. Pharmacology. 2011;88(5-6):327-32. doi: 10.1159/000334339. Epub 2011 Nov 23. Pharmacology. 2011. PMID: 22116077

2

Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents.

Sugawara A, Sueki A, Hirose T, Nagai K, Gouda H, Hirono S, Shima H, Akagawa KS, Omura S, Sunazuka T. Sugawara A, et al. Among authors: omura s. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3373-6. doi: 10.1016/j.bmcl.2011.04.004. Epub 2011 Apr 7. Bioorg Med Chem Lett. 2011. PMID: 21524580

3

Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study.

Sugawara A, Sueki A, Hirose T, Shima H, Akagawa KS, Omura S, Sunazuka T. Sugawara A, et al. Among authors: omura s. J Antibiot (Tokyo). 2012 Sep;65(9):487-90. doi: 10.1038/ja.2012.51. Epub 2012 Jul 4. J Antibiot (Tokyo). 2012. PMID: 22760298 No abstract available.

4

EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: importance in IL-8 transcription.

Li YJ, Shimizu T, Hirata Y, Inagaki H, Takizawa H, Azuma A, Kawada T, Sugawara I, Kudoh S, Sunazuka T, Omura S. Li YJ, et al. Among authors: omura s. Pulm Pharmacol Ther. 2013 Jun;26(3):318-24. doi: 10.1016/j.pupt.2012.12.010. Epub 2013 Jan 3. Pulm Pharmacol Ther. 2013. PMID: 23291319

5

Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium.

Tojima I, Shimizu S, Ogawa T, Kouzaki H, Omura S, Sunazuka T, Shimizu T. Tojima I, et al. Among authors: omura s. Auris Nasus Larynx. 2015 Aug;42(4):332-6. doi: 10.1016/j.anl.2015.02.003. Epub 2015 Mar 10. Auris Nasus Larynx. 2015. PMID: 25769240

6

Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model.

Sugawara A, Shima H, Sueki A, Hirose T, Matsui H, Nakano H, Hanaki H, Akagawa KS, Ōmura S, Sunazuka T. Sugawara A, et al. Among authors: omura s. J Antibiot (Tokyo). 2016 Apr;69(4):319-26. doi: 10.1038/ja.2015.91. Epub 2015 Sep 30. J Antibiot (Tokyo). 2016. PMID: 26419414

7

The non-antibiotic macrolide EM900 inhibits rhinovirus infection and cytokine production in human airway epithelial cells.

Lusamba Kalonji N, Nomura K, Kawase T, Ota C, Kubo H, Sato T, Yanagisawa T, Sunazuka T, Ōmura S, Yamaya M. Lusamba Kalonji N, et al. Among authors: omura s. Physiol Rep. 2015 Oct;3(10):e12557. doi: 10.14814/phy2.12557. Physiol Rep. 2015. PMID: 26462747 Free PMC article.

8

Anti-Inflammatory Effects of EM900 on Cultured Human Nasal Epithelial Cells.

Wakayama N, Matsune S, Takahara E, Sekine K, Yoshioka Y, Ishida M, Yamaguchi S, Okubo K, Sunazuka T, Ōmura S. Wakayama N, et al. Among authors: omura s. J Nippon Med Sch. 2018;85(5):265-270. doi: 10.1272/jnms.JNMS.2018_85-42. J Nippon Med Sch. 2018. PMID: 30464143 Free article.

9

Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity.

Uchimura T, Nakamura DS, Link EM, Noguchi Y, Ōmura S, Sunazuka T, Greenblatt DJ, Zeng L. Uchimura T, et al. Among authors: omura s. Biochem Pharmacol. 2019 Jul;165:79-90. doi: 10.1016/j.bcp.2019.03.014. Epub 2019 Mar 9. Biochem Pharmacol. 2019. PMID: 30862504 Free PMC article.

10

Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation.

Desaki M, Okazaki H, Sunazuka T, Omura S, Yamamoto K, Takizawa H. Desaki M, et al. Among authors: omura s. Antimicrob Agents Chemother. 2004 May;48(5):1581-5. doi: 10.1128/AAC.48.5.1581-1585.2004. Antimicrob Agents Chemother. 2004. PMID: 15105108 Free PMC article.

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