Chen S - Search Results

1

Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors.

Wang J, Wang X, Chen Y, Chen S, Chen G, Tong L, Meng L, Xie Y, Ding J, Yang C. Wang J, et al. Among authors: chen s, chen g, chen y. Bioorg Med Chem Lett. 2012 Jan 1;22(1):339-42. doi: 10.1016/j.bmcl.2011.11.003. Epub 2011 Nov 9. Bioorg Med Chem Lett. 2012. PMID: 22130133

2

New microtubule-inhibiting anticancer agents.

Chen SM, Meng LH, Ding J. Chen SM, et al. Expert Opin Investig Drugs. 2010 Mar;19(3):329-43. doi: 10.1517/13543780903571631. Expert Opin Investig Drugs. 2010. PMID: 20141350 Review.

3

WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant.

Li T, Wang J, Wang X, Yang N, Chen SM, Tong LJ, Yang CH, Meng LH, Ding J. Li T, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):830-8. doi: 10.1124/jpet.110.167940. Epub 2010 Jun 3. J Pharmacol Exp Ther. 2010. PMID: 20522531

4

The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells.

Lu JJ, Chen SM, Zhang XW, Ding J, Meng LH. Lu JJ, et al. Invest New Drugs. 2011 Dec;29(6):1276-83. doi: 10.1007/s10637-010-9481-8. Epub 2010 Jul 7. Invest New Drugs. 2011. PMID: 20607588

5

PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.

Ma JG, Huang H, Chen SM, Chen Y, Xin XL, Lin LP, Ding J, Liu H, Meng LH. Ma JG, et al. Breast Cancer Res Treat. 2011 Nov;130(1):85-96. doi: 10.1007/s10549-010-1302-4. Epub 2010 Dec 22. Breast Cancer Res Treat. 2011. PMID: 21181437

6

Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evaluation of novel inhibitors.

Tong LJ, Xie H, Peng T, Liu XF, Xin XL, Huang X, Chen SM, Liu HY, Li HL, Geng MY, Yin M, Ding J. Tong LJ, et al. Acta Pharmacol Sin. 2011 Jul;32(7):930-8. doi: 10.1038/aps.2011.23. Epub 2011 Jun 6. Acta Pharmacol Sin. 2011. PMID: 21643004 Free PMC article.

7

Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line.

Lu JJ, Chen SM, Ding J, Meng LH. Lu JJ, et al. Mol Cell Biochem. 2012 Jan;360(1-2):329-37. doi: 10.1007/s11010-011-1072-2. Epub 2011 Sep 30. Mol Cell Biochem. 2012. PMID: 21959972

8

Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR.

Chen SM, Liu JL, Wang X, Liang C, Ding J, Meng LH. Chen SM, et al. Biochem Pharmacol. 2012 May 1;83(9):1183-94. doi: 10.1016/j.bcp.2012.01.019. Epub 2012 Jan 26. Biochem Pharmacol. 2012. PMID: 22305748

9

Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells.

Chen G, Chen SM, Wang X, Ding XF, Ding J, Meng LH. Chen G, et al. J Biol Chem. 2012 Apr 6;287(15):12132-41. doi: 10.1074/jbc.M111.302299. Epub 2012 Feb 15. J Biol Chem. 2012. PMID: 22337890 Free PMC article.

10

HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.

Chen SM, Guo CL, Shi JJ, Xu YC, Chen Y, Shen YY, Su Y, Ding J, Meng LH. Chen SM, et al. Int J Cancer. 2014 Nov 15;135(10):2462-74. doi: 10.1002/ijc.28880. Epub 2014 Apr 17. Int J Cancer. 2014. PMID: 24706460

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