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Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?
Bokov AF, Garg N, Ikeno Y, Thakur S, Musi N, DeFronzo RA, Zhang N, Erickson RC, Gelfond J, Hubbard GB, Adamo ML, Richardson A. Bokov AF, et al. Among authors: adamo ml. PLoS One. 2011;6(11):e26891. doi: 10.1371/journal.pone.0026891. Epub 2011 Nov 23. PLoS One. 2011. PMID: 22132081 Free PMC article.
The role of insulin and insulin-like growth factor-I in mammalian ageing.
Richardson A, Liu F, Adamo ML, Van Remmen H, Nelson JF. Richardson A, et al. Among authors: adamo ml. Best Pract Res Clin Endocrinol Metab. 2004 Sep;18(3):393-406. doi: 10.1016/j.beem.2004.02.002. Best Pract Res Clin Endocrinol Metab. 2004. PMID: 15261845 Review.
Reductions in serum IGF-1 during aging impair health span.
Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. Gong Z, et al. Among authors: adamo ml. Aging Cell. 2014 Jun;13(3):408-18. doi: 10.1111/acel.12188. Epub 2013 Dec 30. Aging Cell. 2014. PMID: 24341939 Free PMC article.
Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2.
Nair PN, De Armond DT, Adamo ML, Strodel WE, Freeman JW. Nair PN, et al. Among authors: adamo ml. Oncogene. 2001 Dec 13;20(57):8203-14. doi: 10.1038/sj.onc.1205044. Oncogene. 2001. PMID: 11781836
97 results