Hamel E - Search Results

1

Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

Romagnoli R, Baraldi PG, Salvador MK, Preti D, Aghazadeh Tabrizi M, Brancale A, Fu XH, Li J, Zhang SZ, Hamel E, Bortolozzi R, Basso G, Viola G. Romagnoli R, et al. Among authors: hamel e. J Med Chem. 2012 Jan 12;55(1):475-88. doi: 10.1021/jm2013979. Epub 2011 Dec 21. J Med Chem. 2012. PMID: 22136312 Free PMC article.

2

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1992 Jun 12;35(12):2293-306. doi: 10.1021/jm00090a021. J Med Chem. 1992. PMID: 1613753

3

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1991 Aug;34(8):2579-88. doi: 10.1021/jm00112a036. J Med Chem. 1991. PMID: 1875350

4

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

Cushman M, He HM, Katzenellenbogen JA, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1995 Jun 9;38(12):2041-9. doi: 10.1021/jm00012a003. J Med Chem. 1995. PMID: 7783135

5

Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.

Li L, Wang HK, Kuo SC, Wu TS, Mauger A, Lin CM, Hamel E, Lee KH. Li L, et al. Among authors: hamel e. J Med Chem. 1994 Sep 30;37(20):3400-7. doi: 10.1021/jm00046a025. J Med Chem. 1994. PMID: 7932568

6

Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Li L, Wang HK, Kuo SC, Wu TS, Lednicer D, Lin CM, Hamel E, Lee KH. Li L, et al. Among authors: hamel e. J Med Chem. 1994 Apr 15;37(8):1126-35. doi: 10.1021/jm00034a010. J Med Chem. 1994. PMID: 8164254

7

Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.

Cushman M, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1993 Sep 17;36(19):2817-21. doi: 10.1021/jm00071a012. J Med Chem. 1993. PMID: 8410995

8

Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.

Sun L, Hamel E, Lin CM, Hastie SB, Pyluck A, Lee KH. Sun L, et al. Among authors: hamel e. J Med Chem. 1993 May 14;36(10):1474-9. doi: 10.1021/jm00062a021. J Med Chem. 1993. PMID: 8496915

9

Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.

Sun L, McPhail AT, Hamel E, Lin CM, Hastie SB, Chang JJ, Lee KH. Sun L, et al. Among authors: hamel e. J Med Chem. 1993 Mar 5;36(5):544-51. doi: 10.1021/jm00057a004. J Med Chem. 1993. PMID: 8496935

10

Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.

Shi Q, Verdier-Pinard P, Brossi A, Hamel E, McPhail AT, Lee KH. Shi Q, et al. Among authors: hamel e. J Med Chem. 1997 Mar 14;40(6):961-6. doi: 10.1021/jm960663k. J Med Chem. 1997. PMID: 9083485

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