Aktas BH - Search Results

1

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

Denoyelle S, Chen T, Chen L, Wang Y, Klosi E, Halperin JA, Aktas BH, Chorev M. Denoyelle S, et al. Among authors: aktas bh. Bioorg Med Chem Lett. 2012 Jan 1;22(1):402-9. doi: 10.1016/j.bmcl.2011.10.126. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22153346 Free PMC article.

2

Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.

Ziegeler G, Ming J, Koseki JC, Sevinc S, Chen T, Ergun S, Qin X, Aktas BH. Ziegeler G, et al. Among authors: aktas bh. J Biol Chem. 2010 May 14;285(20):15408-15419. doi: 10.1074/jbc.M110.113365. Epub 2010 Mar 23. J Biol Chem. 2010. PMID: 20332085 Free PMC article.

3

Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis.

Hu W, Ge X, You T, Xu T, Zhang J, Wu G, Peng Z, Chorev M, Aktas BH, Halperin JA, Brown JR, Qin X. Hu W, et al. Among authors: aktas bh. Cancer Res. 2011 Mar 15;71(6):2298-307. doi: 10.1158/0008-5472.CAN-10-3016. Epub 2011 Jan 20. Cancer Res. 2011. PMID: 21252115 Free PMC article.

4

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target.

Chen T, Ozel D, Qiao Y, Harbinski F, Chen L, Denoyelle S, He X, Zvereva N, Supko JG, Chorev M, Halperin JA, Aktas BH. Chen T, et al. Among authors: aktas bh. Nat Chem Biol. 2011 Jul 17;7(9):610-6. doi: 10.1038/nchembio.613. Nat Chem Biol. 2011. PMID: 21765405 Free PMC article.

5

Tumor suppression by small molecule inhibitors of translation initiation.

Chen L, Aktas BH, Wang Y, He X, Sahoo R, Zhang N, Denoyelle S, Kabha E, Yang H, Freedman RY, Supko JG, Chorev M, Wagner G, Halperin JA. Chen L, et al. Among authors: aktas bh. Oncotarget. 2012 Aug;3(8):869-81. doi: 10.18632/oncotarget.598. Oncotarget. 2012. PMID: 22935625 Free PMC article.

6

Dual activators of protein kinase R (PKR) and protein kinase R-like kinase PERK identify common and divergent catalytic targets.

Bai H, Chen T, Ming J, Sun H, Cao P, Fusco DN, Chung RT, Chorev M, Jin Q, Aktas BH. Bai H, et al. Among authors: aktas bh. Chembiochem. 2013 Jul 8;14(10):1255-62. doi: 10.1002/cbic.201300177. Epub 2013 Jun 19. Chembiochem. 2013. PMID: 23784735 Free PMC article.

7

Small-Molecule targeting of translation initiation for cancer therapy.

Aktas BH, Qiao Y, Ozdelen E, Schubert R, Sevinc S, Harbinski F, Grubissich L, Singer S, Halperin JA. Aktas BH, et al. Oncotarget. 2013 Oct;4(10):1606-17. doi: 10.18632/oncotarget.1186. Oncotarget. 2013. PMID: 24091475 Free PMC article.

8

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Denoyelle S, Chen T, Yang H, Chen L, Zhang Y, Halperin JA, Aktas BH, Chorev M. Denoyelle S, et al. Among authors: aktas bh. Eur J Med Chem. 2013 Nov;69:537-53. doi: 10.1016/j.ejmech.2013.08.030. Epub 2013 Sep 17. Eur J Med Chem. 2013. PMID: 24095748

9

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH. Chen T, et al. Among authors: aktas bh. J Med Chem. 2013 Dec 12;56(23):9457-70. doi: 10.1021/jm400793v. Epub 2013 Nov 27. J Med Chem. 2013. PMID: 24261904 Free PMC article.

10

3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.

Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M. Yefidoff-Freedman R, et al. Among authors: aktas bh. Chembiochem. 2014 Mar 3;15(4):595-611. doi: 10.1002/cbic.201300723. Epub 2014 Jan 23. Chembiochem. 2014. PMID: 24458973 Free PMC article.

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