Halperin JA - Search Results

1

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

Denoyelle S, Chen T, Chen L, Wang Y, Klosi E, Halperin JA, Aktas BH, Chorev M. Denoyelle S, et al. Among authors: halperin ja. Bioorg Med Chem Lett. 2012 Jan 1;22(1):402-9. doi: 10.1016/j.bmcl.2011.10.126. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22153346 Free PMC article.

2

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

Natarajan A, Guo Y, Harbinski F, Fan YH, Chen H, Luus L, Diercks J, Aktas H, Chorev M, Halperin JA. Natarajan A, et al. Among authors: halperin ja. J Med Chem. 2004 Oct 7;47(21):4979-82. doi: 10.1021/jm0496234. J Med Chem. 2004. PMID: 15456240

3

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target.

Chen T, Ozel D, Qiao Y, Harbinski F, Chen L, Denoyelle S, He X, Zvereva N, Supko JG, Chorev M, Halperin JA, Aktas BH. Chen T, et al. Among authors: halperin ja. Nat Chem Biol. 2011 Jul 17;7(9):610-6. doi: 10.1038/nchembio.613. Nat Chem Biol. 2011. PMID: 21765405 Free PMC article.

4

Tumor suppression by small molecule inhibitors of translation initiation.

Chen L, Aktas BH, Wang Y, He X, Sahoo R, Zhang N, Denoyelle S, Kabha E, Yang H, Freedman RY, Supko JG, Chorev M, Wagner G, Halperin JA. Chen L, et al. Among authors: halperin ja. Oncotarget. 2012 Aug;3(8):869-81. doi: 10.18632/oncotarget.598. Oncotarget. 2012. PMID: 22935625 Free PMC article.

5

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Denoyelle S, Chen T, Yang H, Chen L, Zhang Y, Halperin JA, Aktas BH, Chorev M. Denoyelle S, et al. Among authors: halperin ja. Eur J Med Chem. 2013 Nov;69:537-53. doi: 10.1016/j.ejmech.2013.08.030. Epub 2013 Sep 17. Eur J Med Chem. 2013. PMID: 24095748

6

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M. Takrouri K, et al. Among authors: halperin ja. Eur J Med Chem. 2014 Apr 22;77:361-77. doi: 10.1016/j.ejmech.2014.03.034. Epub 2014 Mar 13. Eur J Med Chem. 2014. PMID: 24675136 Free PMC article.

7

Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction.

Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M. Mahalingam P, et al. Among authors: halperin ja. J Med Chem. 2014 Jun 26;57(12):5094-111. doi: 10.1021/jm401733v. Epub 2014 Jun 4. J Med Chem. 2014. PMID: 24827861 Free PMC article.

8

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH. Chen T, et al. J Med Chem. 2013 Dec 12;56(23):9457-70. doi: 10.1021/jm400793v. Epub 2013 Nov 27. J Med Chem. 2013. PMID: 24261904 Free PMC article.

9

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response.

Yefidoff-Freedman R, Fan J, Yan L, Zhang Q, Dos Santos GRR, Rana S, Contreras JI, Sahoo R, Wan D, Young J, Dias Teixeira KL, Morisseau C, Halperin J, Hammock B, Natarajan A, Wang P, Chorev M, Aktas BH. Yefidoff-Freedman R, et al. J Med Chem. 2017 Jul 13;60(13):5392-5406. doi: 10.1021/acs.jmedchem.7b00059. Epub 2017 Jun 19. J Med Chem. 2017. PMID: 28590739 Free PMC article.

10

New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties.

Zhang Q, Du R, Reis Monteiro Dos Santos GR, Yefidoff-Freedman R, Bohm A, Halperin J, Chorev M, Aktas BH. Zhang Q, et al. Eur J Med Chem. 2020 Feb 1;187:111973. doi: 10.1016/j.ejmech.2019.111973. Epub 2019 Dec 16. Eur J Med Chem. 2020. PMID: 31881453

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