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Cancer stem cells: never Wnt away from the niche.
Malanchi I, Huelsken J. Malanchi I, et al. Curr Opin Oncol. 2009 Jan;21(1):41-6. doi: 10.1097/CCO.0b013e32831d1faf. Curr Opin Oncol. 2009. PMID: 19125017 Review.
Metastatic-niche labelling reveals parenchymal cells with stem features.
Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH, Malanchi I. Ombrato L, et al. Among authors: malanchi i. Nature. 2019 Aug;572(7771):603-608. doi: 10.1038/s41586-019-1487-6. Epub 2019 Aug 28. Nature. 2019. PMID: 31462798 Free PMC article.
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling.
Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Liu XZ, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de la Calle Arregui C, Floris G, Swinnen JV, Marine JC, Lambrechts D, Pelechano V, Mazzone M, Zanivan S, Cools J, Wildiers H, Baud V, Grünewald TGP, Ben-David U, Desmedt C, Malanchi I, Fendt SM. Altea-Manzano P, et al. Among authors: malanchi i. Nat Cancer. 2023 Mar;4(3):344-364. doi: 10.1038/s43018-023-00513-2. Epub 2023 Feb 2. Nat Cancer. 2023. PMID: 36732635 Free PMC article.
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
Blaas L, Pucci F, Messal HA, Andersson AB, Josue Ruiz E, Gerling M, Douagi I, Spencer-Dene B, Musch A, Mitter R, Bhaw L, Stone R, Bornhorst D, Sesay AK, Jonkers J, Stamp G, Malanchi I, Toftgård R, Behrens A. Blaas L, et al. Among authors: malanchi i. Nat Cell Biol. 2016 Dec;18(12):1346-1356. doi: 10.1038/ncb3434. Epub 2016 Oct 31. Nat Cell Biol. 2016. PMID: 27798604 Free PMC article.
54 results