O'Kane TM - Search Results

1

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.

Zificsak CA, Gingrich DE, Breslin HJ, Dunn DD, Milkiewicz KL, Theroff JP, Thieu TV, Underiner TL, Weinberg LR, Aimone LD, Albom MS, Mason JL, Saville L, Husten J, Angeles TS, Finn JP, Jan M, O'Kane TM, Dobrzanski P, Dorsey BD. Zificsak CA, et al. Among authors: o kane tm. Bioorg Med Chem Lett. 2012 Jan 1;22(1):133-7. doi: 10.1016/j.bmcl.2011.11.049. Epub 2011 Nov 25. Bioorg Med Chem Lett. 2012. PMID: 22169263

2

Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer.

Seavey MM, Lu LD, Stump KL, Wallace NH, Hockeimer W, O'Kane TM, Ruggeri BA, Dobrzanski P. Seavey MM, et al. Among authors: o kane tm. Mol Cancer Ther. 2012 Apr;11(4):984-93. doi: 10.1158/1535-7163.MCT-11-0951. Epub 2012 Feb 14. Mol Cancer Ther. 2012. PMID: 22334590

3

Mixed lineage kinase activity of indolocarbazole analogues.

Murakata C, Kaneko M, Gessner G, Angeles TS, Ator MA, O'Kane TM, McKenna BA, Thomas BA, Mathiasen JR, Saporito MS, Bozyczko-Coyne D, Hudkins RL. Murakata C, et al. Among authors: o kane tm. Bioorg Med Chem Lett. 2002 Jan 21;12(2):147-50. doi: 10.1016/s0960-894x(01)00690-4. Bioorg Med Chem Lett. 2002. PMID: 11755341

4

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis.

Bozyczko-Coyne D, O'Kane TM, Wu ZL, Dobrzanski P, Murthy S, Vaught JL, Scott RW. Bozyczko-Coyne D, et al. Among authors: o kane tm. J Neurochem. 2001 May;77(3):849-63. doi: 10.1046/j.1471-4159.2001.00294.x. J Neurochem. 2001. PMID: 11331414 Free article.

5

CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults.

Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, Park DS, Yan CY, Troy CM, Greene LA. Maroney AC, et al. Among authors: o kane tm. J Neurochem. 1999 Nov;73(5):1901-12. J Neurochem. 1999. PMID: 10537048 Free article.

6

D-amino acid containing, high-affinity inhibitors of recombinant human calpain I.

Chatterjee S, Gu ZQ, Dunn D, Tao M, Josef K, Tripathy R, Bihovsky R, Senadhi SE, O'Kane TM, McKenna BA, Mallya S, Ator MA, Bozyczko-Coyne D, Siman R, Mallamo JP. Chatterjee S, et al. Among authors: o kane tm. J Med Chem. 1998 Jul 16;41(15):2663-6. doi: 10.1021/jm980035y. J Med Chem. 1998. PMID: 9667954 No abstract available.

7

Exploration of the importance of the P2-P3-NHCO-moiety in a potent di- or tripeptide inhibitor of calpain I: insights into the development of nonpeptidic inhibitors of calpain I.

Chatterjee S, Iqbal M, Mallya S, Senadhi SE, O'Kane TM, McKenna BA, Bozyczko-Coyne D, Kauer JC, Siman R, Mallamo JP. Chatterjee S, et al. Among authors: o kane tm. Bioorg Med Chem. 1998 May;6(5):509-22. doi: 10.1016/s0968-0896(98)00009-1. Bioorg Med Chem. 1998. PMID: 9629465

8

Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I.

Chatterjee S, Ator MA, Bozyczko-Coyne D, Josef K, Wells G, Tripathy R, Iqbal M, Bihovsky R, Senadhi SE, Mallya S, O'Kane TM, McKenna BA, Siman R, Mallamo JP. Chatterjee S, et al. J Med Chem. 1997 Nov 7;40(23):3820-8. doi: 10.1021/jm970197e. J Med Chem. 1997. PMID: 9371247

9

Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion.

Wu ZL, O'Kane TM, Scott RW, Savage MJ, Bozyczko-Coyne D. Wu ZL, et al. Among authors: o kane tm. J Biol Chem. 2002 Nov 15;277(46):44208-13. doi: 10.1074/jbc.M206890200. Epub 2002 Sep 10. J Biol Chem. 2002. PMID: 12226089 Free article.

10

The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.

Wu ZL, O'Kane TM, Connors TJ, Marino MJ, Schaffhauser H. Wu ZL, et al. Among authors: o kane tm. Brain Res. 2008 Aug 28;1227:42-51. doi: 10.1016/j.brainres.2008.06.078. Epub 2008 Jun 28. Brain Res. 2008. PMID: 18621031

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