Logothetis DE - Search Results

1

Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.

Deng W, Bukiya AN, Rodríguez-Menchaca AA, Zhang Z, Baumgarten CM, Logothetis DE, Levitan I, Rosenhouse-Dantsker A. Deng W, et al. Among authors: logothetis de. J Biol Chem. 2012 Feb 10;287(7):4925-35. doi: 10.1074/jbc.M111.306134. Epub 2011 Dec 15. J Biol Chem. 2012. PMID: 22174416 Free PMC article.

2

Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol.

Epshtein Y, Chopra AP, Rosenhouse-Dantsker A, Kowalsky GB, Logothetis DE, Levitan I. Epshtein Y, et al. Among authors: logothetis de. Proc Natl Acad Sci U S A. 2009 May 12;106(19):8055-60. doi: 10.1073/pnas.0809847106. Epub 2009 Apr 29. Proc Natl Acad Sci U S A. 2009. PMID: 19416905 Free PMC article.

3

Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop.

Rosenhouse-Dantsker A, Leal-Pinto E, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. Among authors: logothetis de. Channels (Austin). 2010 Jan-Feb;4(1):63-6. doi: 10.4161/chan.4.1.10366. Epub 2010 Jan 20. Channels (Austin). 2010. PMID: 19923917 Free PMC article.

4

Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore.

Rosenhouse-Dantsker A, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. Among authors: logothetis de. Biophys J. 2011 Jan 19;100(2):381-9. doi: 10.1016/j.bpj.2010.11.086. Biophys J. 2011. PMID: 21244834 Free PMC article.

5

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. Among authors: logothetis de. J Biol Chem. 2012 Nov 23;287(48):40266-78. doi: 10.1074/jbc.M111.336339. Epub 2012 Sep 20. J Biol Chem. 2012. PMID: 22995912 Free PMC article.

6

Identification of novel cholesterol-binding regions in Kir2 channels.

Rosenhouse-Dantsker A, Noskov S, Durdagi S, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. Among authors: logothetis de. J Biol Chem. 2013 Oct 25;288(43):31154-64. doi: 10.1074/jbc.M113.496117. Epub 2013 Sep 9. J Biol Chem. 2013. PMID: 24019518 Free PMC article.

7

Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition.

Tang QY, Zhang Z, Xia J, Ren D, Logothetis DE. Tang QY, et al. Among authors: logothetis de. J Biol Chem. 2010 Jun 18;285(25):19259-66. doi: 10.1074/jbc.M109.100156. Epub 2010 Apr 14. J Biol Chem. 2010. PMID: 20392696 Free PMC article.

8

Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.

Rosenhouse-Dantsker A, Noskov S, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. Among authors: logothetis de. Channels (Austin). 2013 Jul-Aug;7(4):303-12. doi: 10.4161/chan.25437. Epub 2013 Jun 27. Channels (Austin). 2013. PMID: 23807091 Free PMC article.

9

Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix.

Rosenhouse-Dantsker A, Logothetis DE. Rosenhouse-Dantsker A, et al. Among authors: logothetis de. Channels (Austin). 2007 May-Jun;1(3):189-97. doi: 10.4161/chan.4475. Epub 2007 May 23. Channels (Austin). 2007. PMID: 18690025 Free article.

10

A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).

Rosenhouse-Dantsker A, Sui JL, Zhao Q, Rusinova R, Rodríguez-Menchaca AA, Zhang Z, Logothetis DE. Rosenhouse-Dantsker A, et al. Among authors: logothetis de. Nat Chem Biol. 2008 Oct;4(10):624-31. doi: 10.1038/nchembio.112. Epub 2008 Sep 14. Nat Chem Biol. 2008. PMID: 18794864 Free PMC article.

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