Phan K - Search Results

1

Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.

Tosh DK, Phan K, Deflorian F, Wei Q, Yoo LS, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: phan k. Bioconjug Chem. 2012 Feb 15;23(2):232-47. doi: 10.1021/bc200526c. Epub 2012 Jan 11. Bioconjug Chem. 2012. PMID: 22175234 Free PMC article.

2

Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.

Kumar TS, Mishra S, Deflorian F, Yoo LS, Phan K, Kecskés M, Szabo A, Shinkre B, Gao ZG, Trenkle W, Jacobson KA. Kumar TS, et al. Among authors: phan k. Bioorg Med Chem Lett. 2011 May 1;21(9):2740-5. doi: 10.1016/j.bmcl.2010.11.082. Epub 2010 Nov 21. Bioorg Med Chem Lett. 2011. PMID: 21185184 Free PMC article.

3

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element.

Tosh DK, Phan K, Deflorian F, Wei Q, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: phan k. ACS Med Chem Lett. 2011 Aug 11;2(8):626-631. doi: 10.1021/ml200114q. ACS Med Chem Lett. 2011. PMID: 21858244 Free PMC article.

4

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Deflorian F, Kumar TS, Phan K, Gao ZG, Xu F, Wu H, Katritch V, Stevens RC, Jacobson KA. Deflorian F, et al. Among authors: phan k. J Med Chem. 2012 Jan 12;55(1):538-52. doi: 10.1021/jm201461q. Epub 2011 Dec 12. J Med Chem. 2012. PMID: 22104008 Free PMC article.

5

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.

Kozma E, Kumar TS, Federico S, Phan K, Balasubramanian R, Gao ZG, Paoletta S, Moro S, Spalluto G, Jacobson KA. Kozma E, et al. Among authors: phan k. Biochem Pharmacol. 2012 Jun 1;83(11):1552-61. doi: 10.1016/j.bcp.2012.02.019. Epub 2012 Mar 1. Biochem Pharmacol. 2012. PMID: 22402302 Free PMC article.

6

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.

Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Tosh DK, et al. Among authors: phan k. J Med Chem. 2012 May 10;55(9):4297-308. doi: 10.1021/jm300095s. Epub 2012 Apr 30. J Med Chem. 2012. PMID: 22486652 Free PMC article.

7

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

Tosh DK, Deflorian F, Phan K, Gao ZG, Wan TC, Gizewski E, Auchampach JA, Jacobson KA. Tosh DK, et al. Among authors: phan k. J Med Chem. 2012 May 24;55(10):4847-60. doi: 10.1021/jm300396n. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559880 Free PMC article.

8

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

Tosh DK, Paoletta S, Deflorian F, Phan K, Moss SM, Gao ZG, Jiang X, Jacobson KA. Tosh DK, et al. Among authors: phan k. J Med Chem. 2012 Sep 27;55(18):8075-90. doi: 10.1021/jm300965a. Epub 2012 Sep 10. J Med Chem. 2012. PMID: 22921089 Free PMC article.

9

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.

Tosh DK, Paoletta S, Phan K, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: phan k. ACS Med Chem Lett. 2012 Jul 12;3(7):596-601. doi: 10.1021/ml300107e. Epub 2012 Jun 11. ACS Med Chem Lett. 2012. PMID: 23145215 Free PMC article.

10

Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A₃ Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary.

Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Lee Y, et al. Among authors: phan k. J Med Chem. 2021 Sep 9;64(17):12525-12536. doi: 10.1021/acs.jmedchem.1c00239. Epub 2021 Aug 26. J Med Chem. 2021. PMID: 34435786 Free PMC article.

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