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Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.
Chinetti-Gbaguidi G, Baron M, Bouhlel MA, Vanhoutte J, Copin C, Sebti Y, Derudas B, Mayi T, Bories G, Tailleux A, Haulon S, Zawadzki C, Jude B, Staels B. Chinetti-Gbaguidi G, et al. Circ Res. 2011 Apr 15;108(8):985-95. doi: 10.1161/CIRCRESAHA.110.233775. Epub 2011 Feb 24. Circ Res. 2011. PMID: 21350215 Free PMC article.
Human adipose tissue macrophages display activation of cancer-related pathways.
Mayi TH, Daoudi M, Derudas B, Gross B, Bories G, Wouters K, Brozek J, Caiazzo R, Raverdi V, Pigeyre M, Allavena P, Mantovani A, Pattou F, Staels B, Chinetti-Gbaguidi G. Mayi TH, et al. J Biol Chem. 2012 Jun 22;287(26):21904-13. doi: 10.1074/jbc.M111.315200. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511784 Free PMC article.
The neuron-derived orphan receptor 1 (NOR1) is induced upon human alternative macrophage polarization and stimulates the expression of markers of the M2 phenotype.
De Paoli F, Eeckhoute J, Copin C, Vanhoutte J, Duhem C, Derudas B, Dubois-Chevalier J, Colin S, Zawadzki C, Jude B, Haulon S, Lefebvre P, Staels B, Chinetti-Gbaguidi G. De Paoli F, et al. Among authors: chinetti gbaguidi g. Atherosclerosis. 2015 Jul;241(1):18-26. doi: 10.1016/j.atherosclerosis.2015.04.798. Epub 2015 Apr 26. Atherosclerosis. 2015. PMID: 25941992
PPARβ in macrophages and atherosclerosis.
Chinetti-Gbaguidi G, Staels B. Chinetti-Gbaguidi G, et al. Biochimie. 2017 May;136:59-64. doi: 10.1016/j.biochi.2016.12.008. Epub 2016 Dec 21. Biochimie. 2017. PMID: 28011212 Free article. Review.
51 results