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Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.
Gupta A, Akki A, Wang Y, Leppo MK, Chacko VP, Foster DB, Caceres V, Shi S, Kirk JA, Su J, Lai S, Paolocci N, Steenbergen C, Gerstenblith G, Weiss RG. Gupta A, et al. Among authors: steenbergen c. J Clin Invest. 2012 Jan;122(1):291-302. doi: 10.1172/JCI57426. Epub 2011 Dec 27. J Clin Invest. 2012. PMID: 22201686 Free PMC article.
Skeletal muscle ATP kinetics are impaired in frail mice.
Akki A, Yang H, Gupta A, Chacko VP, Yano T, Leppo MK, Steenbergen C, Walston J, Weiss RG. Akki A, et al. Among authors: steenbergen c. Age (Dordr). 2014 Feb;36(1):21-30. doi: 10.1007/s11357-013-9540-0. Epub 2013 May 22. Age (Dordr). 2014. PMID: 23695949 Free PMC article.
Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure.
Keceli G, Gupta A, Sourdon J, Gabr R, Schär M, Dey S, Tocchetti CG, Stuber A, Agrimi J, Zhang Y, Leppo M, Steenbergen C, Lai S, Yanek LR, O'Rourke B, Gerstenblith G, Bottomley PA, Wang Y, Paolocci N, Weiss RG. Keceli G, et al. Among authors: steenbergen c. Circ Res. 2022 Mar 4;130(5):741-759. doi: 10.1161/CIRCRESAHA.121.319648. Epub 2022 Feb 3. Circ Res. 2022. PMID: 35109669 Free PMC article.
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy.
Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Lai S, Steenbergen C, Gerstenblith G, Lange R, Marbán E. Johnston PV, et al. Among authors: steenbergen c. Circulation. 2009 Sep 22;120(12):1075-83, 7 p following 1083. doi: 10.1161/CIRCULATIONAHA.108.816058. Epub 2009 Sep 8. Circulation. 2009. PMID: 19738142 Free PMC article.
ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.
Belmonte F, Das S, Sysa-Shah P, Sivakumaran V, Stanley B, Guo X, Paolocci N, Aon MA, Nagane M, Kuppusamy P, Steenbergen C, Gabrielson K. Belmonte F, et al. Among authors: steenbergen c. Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1271-80. doi: 10.1152/ajpheart.00517.2014. Epub 2015 Aug 7. Am J Physiol Heart Circ Physiol. 2015. PMID: 26254336 Free PMC article.
209 results