Kamath AV - Search Results

1

Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose.

Kamath AV, Lu D, Gupta P, Jin D, Xiang H, Wong A, Leddy C, Crocker L, Schaefer G, Sliwkowski MX, Damico-Beyer LA. Kamath AV, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):1063-9. doi: 10.1007/s00280-011-1806-6. Epub 2011 Dec 28. Cancer Chemother Pharmacol. 2012. PMID: 22203367

2

P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.

Kamath AV, Chong S, Chang M, Marathe PH. Kamath AV, et al. Cancer Chemother Pharmacol. 2005 Feb;55(2):110-6. doi: 10.1007/s00280-004-0873-3. Epub 2004 Aug 27. Cancer Chemother Pharmacol. 2005. PMID: 15338193

3

Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog.

Kamath AV, Chang M, Lee FY, Zhang Y, Marathe PH. Kamath AV, et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):145-53. doi: 10.1007/s00280-004-0928-5. Epub 2005 Apr 14. Cancer Chemother Pharmacol. 2005. PMID: 15830240

4

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL.

Kamath AV, Wang J, Lee FY, Marathe PH. Kamath AV, et al. Cancer Chemother Pharmacol. 2008 Mar;61(3):365-76. doi: 10.1007/s00280-007-0478-8. Epub 2007 Apr 11. Cancer Chemother Pharmacol. 2008. PMID: 17429625

5

Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate.

Marathe PH, Kamath AV, Zhang Y, D'Arienzo C, Bhide R, Fargnoli J. Marathe PH, et al. Among authors: kamath av. Cancer Chemother Pharmacol. 2009 Dec;65(1):55-66. doi: 10.1007/s00280-009-1002-0. Epub 2009 Apr 26. Cancer Chemother Pharmacol. 2009. PMID: 19396600

6

Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma.

Kamath AV, Lu D, Gupta P, Jin D, Xin Y, Brady A, Stephan JP, Li H, Tien J, Qing J, Damico-Beyer LA. Kamath AV, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):1071-8. doi: 10.1007/s00280-011-1807-5. Epub 2011 Dec 28. Cancer Chemother Pharmacol. 2012. PMID: 22203368

7

Engineering upper hinge improves stability and effector function of a human IgG1.

Yan B, Boyd D, Kaschak T, Tsukuda J, Shen A, Lin Y, Chung S, Gupta P, Kamath A, Wong A, Vernes JM, Meng GY, Totpal K, Schaefer G, Jiang G, Nogal B, Emery C, Vanderlaan M, Carter P, Harris R, Amanullah A. Yan B, et al. J Biol Chem. 2012 Feb 17;287(8):5891-7. doi: 10.1074/jbc.M111.311811. Epub 2011 Dec 27. J Biol Chem. 2012. PMID: 22203673 Free PMC article.

8

Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging.

Kamath AV, Williams SP, Bullens S, Cowan KJ, Stenberg Y, Cherry SR, Rendig S, Kukis DL, Griesemer C, Damico-Beyer LA, Bunting S. Kamath AV, et al. PLoS One. 2012;7(9):e45116. doi: 10.1371/journal.pone.0045116. Epub 2012 Sep 17. PLoS One. 2012. PMID: 23028793 Free PMC article.

9

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates.

Kamath AV, Iyer S. Kamath AV, et al. Pharm Res. 2015 Nov;32(11):3470-9. doi: 10.1007/s11095-014-1584-z. Epub 2014 Dec 2. Pharm Res. 2015. PMID: 25446773 Free PMC article. Review.

10

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Kamath AV, et al. MAbs. 2014;6(6):1631-7. doi: 10.4161/mabs.36107. MAbs. 2014. PMID: 25484068 Free PMC article.

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