Wilderman PR - Search Results

1

Plasticity of CYP2B enzymes: structural and solution biophysical methods.

Wilderman PR, Halpert JR. Wilderman PR, et al. Curr Drug Metab. 2012 Feb;13(2):167-76. doi: 10.2174/138920012798918417. Curr Drug Metab. 2012. PMID: 22208531 Free PMC article. Review.

2

Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334.

Talakad JC, Wilderman PR, Davydov DR, Kumar S, Halpert JR. Talakad JC, et al. Among authors: wilderman pr. Arch Biochem Biophys. 2010 Feb 15;494(2):151-8. doi: 10.1016/j.abb.2009.11.026. Epub 2009 Nov 26. Arch Biochem Biophys. 2010. PMID: 19944064 Free PMC article.

3

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR. Gay SC, et al. Among authors: wilderman pr. Mol Pharmacol. 2010 Apr;77(4):529-38. doi: 10.1124/mol.109.062570. Epub 2010 Jan 8. Mol Pharmacol. 2010. PMID: 20061448 Free PMC article.

4

Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography.

Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL Jr, Stout CD, Halpert JR. Wilderman PR, et al. J Biol Chem. 2010 Dec 3;285(49):38602-11. doi: 10.1074/jbc.M110.180646. Epub 2010 Sep 28. J Biol Chem. 2010. PMID: 20880847 Free PMC article.

5

Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.

Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL Jr, Stout CD, Hollenberg PF, Halpert JR. Gay SC, et al. Among authors: wilderman pr. Biochemistry. 2011 Jun 7;50(22):4903-11. doi: 10.1021/bi200482g. Epub 2011 May 13. Biochemistry. 2011. PMID: 21510666 Free PMC article.

6

Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.

Wilderman PR, Gay SC, Jang HH, Zhang Q, Stout CD, Halpert JR. Wilderman PR, et al. FEBS J. 2012 May;279(9):1607-20. doi: 10.1111/j.1742-4658.2011.08411.x. Epub 2011 Nov 25. FEBS J. 2012. PMID: 22051155 Free PMC article.

7

Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.

Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: wilderman pr. Biochemistry. 2012 Sep 18;51(37):7225-38. doi: 10.1021/bi300894z. Epub 2012 Sep 4. Biochemistry. 2012. PMID: 22909231 Free PMC article.

8

Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6.

Wilderman PR, Shah MB, Jang HH, Stout CD, Halpert JR. Wilderman PR, et al. J Am Chem Soc. 2013 Jul 17;135(28):10433-40. doi: 10.1021/ja403042k. Epub 2013 Jul 3. J Am Chem Soc. 2013. PMID: 23786449 Free PMC article.

9

Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.

Shah MB, Wilderman PR, Liu J, Jang HH, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: wilderman pr. Mol Pharmacol. 2015 Apr;87(4):649-59. doi: 10.1124/mol.114.097014. Epub 2015 Jan 13. Mol Pharmacol. 2015. PMID: 25585967 Free PMC article.

10

Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.

Jang HH, Liu J, Lee GY, Halpert JR, Wilderman PR. Jang HH, et al. Among authors: wilderman pr. Arch Biochem Biophys. 2015 Oct 15;584:61-9. doi: 10.1016/j.abb.2015.08.007. Epub 2015 Aug 28. Arch Biochem Biophys. 2015. PMID: 26319176 Free PMC article.

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