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Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.
Ibrahim MA, Johnson HW, Jeong JW, Lewis GL, Shi X, Noguchi RT, Williams M, Leahy JW, Nuss JM, Woolfrey J, Banica M, Bentzien F, Chou YC, Gibson A, Heald N, Lamb P, Mattheakis L, Matthews D, Shipway A, Wu X, Zhang W, Zhou S, Shankar G. Ibrahim MA, et al. J Med Chem. 2012 Feb 9;55(3):1368-81. doi: 10.1021/jm201533b. Epub 2012 Jan 24. J Med Chem. 2012. PMID: 22214363
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Forsyth T, Kearney PC, Kim BG, Johnson HW, Aay N, Arcalas A, Brown DS, Chan V, Chen J, Du H, Epshteyn S, Galan AA, Huynh TP, Ibrahim MA, Kane B, Koltun ES, Mann G, Meyr LE, Lee MS, Lewis GL, Noguchi RT, Pack M, Ridgway BH, Shi X, Takeuchi CS, Zu P, Leahy JW, Nuss JM, Aoyama R, Engst S, Gendreau SB, Kassees R, Li J, Lin SH, Martini JF, Stout T, Tong P, Woolfrey J, Zhang W, Yu P. Forsyth T, et al. Among authors: ibrahim ma. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7653-8. doi: 10.1016/j.bmcl.2012.10.007. Epub 2012 Oct 16. Bioorg Med Chem Lett. 2012. PMID: 23127890
Synthesis and antiproliferative effects of 5,6-disubstituted Pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 Analogues.
Elagawany M, Schmitt M, Ghiaty A, El-Etrawy ASh, Ibrahim MA, Bihel F, Sbardelotto AB, Pessoa C, Nguyen TL, Hamel E, Bourguignon JJ. Elagawany M, et al. Among authors: ibrahim ma. Anticancer Agents Med Chem. 2013 Sep;13(7):1133-40. doi: 10.2174/1871520611313070018. Anticancer Agents Med Chem. 2013. PMID: 23574386 Free PMC article.
Gabapentin hybrid peptides and bioconjugates.
Lebedyeva IO, Ostrov DA, Neubert J, Steel PJ, Patel K, Sileno SM, Goncalves K, Ibrahim MA, Alamry KA, Katritzky AR. Lebedyeva IO, et al. Among authors: ibrahim ma. Bioorg Med Chem. 2014 Feb 15;22(4):1479-86. doi: 10.1016/j.bmc.2013.12.017. Epub 2013 Dec 12. Bioorg Med Chem. 2014. PMID: 24468631
1,062 results