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The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential.
François KO, Pannecouque C, Auwerx J, Lozano V, Pérez-Pérez MJ, Schols D, Balzarini J. François KO, et al. Antimicrob Agents Chemother. 2009 Nov;53(11):4852-9. doi: 10.1128/AAC.00811-09. Epub 2009 Aug 31. Antimicrob Agents Chemother. 2009. PMID: 19721061 Free PMC article.
Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
Balzarini J, François KO, Van Laethem K, Hoorelbeke B, Renders M, Auwerx J, Liekens S, Oki T, Igarashi Y, Schols D. Balzarini J, et al. Among authors: francois ko. Antimicrob Agents Chemother. 2010 Apr;54(4):1425-35. doi: 10.1128/AAC.01347-09. Epub 2010 Jan 4. Antimicrob Agents Chemother. 2010. PMID: 20047920 Free PMC article.
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope.
Hoorelbeke B, Huskens D, Férir G, François KO, Takahashi A, Van Laethem K, Schols D, Tanaka H, Balzarini J. Hoorelbeke B, et al. Among authors: francois ko. Antimicrob Agents Chemother. 2010 Aug;54(8):3287-301. doi: 10.1128/AAC.00254-10. Epub 2010 May 24. Antimicrob Agents Chemother. 2010. PMID: 20498311 Free PMC article.
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